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Clinical Implications of Basic Research
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Volume 348:643-644 February 13, 2003 Number 7
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In Search of a Better HIV Vaccine — The Heat Is On
Elizabeth G. Phimister, Ph.D.

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Human immunodeficiency virus type 1 (HIV-1) is notorious for its ability to evade the immune system. A recent study by Kwong and colleagues1 has uncovered a new molecular mechanism of antibody evasion that points toward a better strategy for the development of a vaccine.

The authors explored the perplexing question of why most antibodies generated against the receptor-binding surface — a highly conserved part of the HIV-1 envelope that is exposed to the immune system — fail to neutralize the virus (Figure 1). They measured two types of changes that occur when individual antibodies bind to glycoprotein 120: . . . [Full Text of this Article]



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