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Correspondence
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Volume 348:759-760 February 20, 2003 Number 8
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Genomic Medicine

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 by Guttmacher, A. E.
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To the Editor: The first case vignette in Guttmacher and Collins's primer on genomic medicine (Nov. 7 issue)1 is not a good example of the value of genomic medicine; rather, it may be an example of excessive laboratory testing. Heparin prophylaxis during pregnancy would be indicated for Kathleen, the woman described in the vignette, on the clinical basis of her prior estrogen-related deep venous thrombosis, even if she were not heterozygous for the factor V Leiden mutation.2 Conversely, although she is heterozygous for the factor V Leiden mutation, heparin prophylaxis would not be indicated if she had never had an . . . [Full Text of this Article]




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