In this issue of the Journal, Sieber et al.1 report that upto 30 percent of cases of multiple colorectal adenomas (15 to100 adenomas) might be linked to biallelic mutations in theMYH gene. What are the implications of this finding for thediagnosis and management of this disease?
Isolated adenomatous polyps are found in the colon in many persons,especially after 50 years of age. Since 5 to 10 percent of theselesions undergo malignant transformation over the course ofseveral years, the endoscopist will reduce the risk of cancerby removing them. In the rare instances in . . . [Full Text of this Article]
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From the Institute of Medical Radiobiology, University of Zurich, Zurich, Switzerland.
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