To the Editor: Immunocompromised patients can persistently shedinfluenza, increasing the potential for resistance to antiviraldrugs and for nosocomial transmission.1,2 We report the caseof a 23-year-old man with acute lymphocytic leukemia who underwenttransplantation of T-celldepleted hematopoietic stemcells from his HLA-mismatched brother in August 1999 after receivingtotal body irradiation, thiotepa, fludarabine, and antithymocyteglobulin. After transplantation, graft-versus-host disease developed(requiring treatment with prednisone and azathioprine), alongwith transplant-related nephropathy, avascular necrosis in bothankles, and restrictive lung disease.
In January 2001, rhinorrhea, cough, and fever developed. Computedtomographic scanning showed mucosal thickening in the maxillary,ethmoid, . . . [Full Text of this Article]
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