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The idea that excessive exercise or undernutrition can postpone puberty, reduce fertility, or prevent menstruation is now so embedded in the body of medical knowledge that it is hard to believe that Frisch's pioneering studies, beginning in the late 1960s, of the reproductive consequences of an altered mass of depot fat were largely ignored or treated with skepticism. Her hypothesis that a critical mass of body fat is the crucial trigger of gonadotropin secretion, both in developing girls and in mature women during reproductive life was initially based on detailed analysis of worldwide demographic data and was later
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