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Previous Volume 349:926-928 September 4, 2003 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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New insights into the complex metabolic circuitry of energy homeostasis have refined our understanding of the pathophysiology of obesity. Some of these insights regarding energy homeostasis are based on the identification of new functions for peptides that were discovered decades ago (see Figure). It is now known that -melanocyte–stimulating hormone, a peptide derived from proopiomelanocortin and long recognized for its role in skin pigmentation through activity at the melanocortin 1 receptor (MC1R), decreases food intake and increases energy expenditure through interaction in the hypothalamus with another melanocortin receptor, MC4R. In mice, targeted deletion of the Mc4r gene results in . . . [Full Text of this Article]

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From the College of Physicians and Surgeons, Columbia University, New York.

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Inhibition of Food Intake by Peptide YY_3–36
DeSantis M. E., Korner J., Leibel R. L.
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N Engl J Med 2003; 349:2365-2366, Dec 11, 2003. Correspondence

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