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Previous Volume 349:969-974 September 4, 2003 Number 10 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Editorial by Guttmacher, A. E. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

Although our understanding of pathology has grown rapidly in recent decades, the underlying mechanisms of many diseases remain obscure. Genomic research offers a new opportunity for determining how diseases occur, by taking advantage of experiments of nature and a growing array of sophisticated research tools to identify the molecular abnormalities underlying disease processes.¹ In this review I examine examples in which genomic research has improved our understanding of molecular pathobiology and consider its potential for contributing to the study of common complex diseases.

Effect of Mutations on the Severity of Hemophilia A

Before the advent of therapy for hemophilia A, some affected patients had only moderate bleeding problems, lived . . . [Full Text of this Article]

Reclassification of the Dystrophinopathies through Genomic Understanding

Variable Effect of the Same Genotype on Health Outcomes in Cystic Fibrosis

Genetic Variants as a Common Phenomenon

Asthma as an Example of the Genetics of Common Complex Diseases

Conclusions

Source Information

From the Department of Medical History and Ethics, University of Washington, Seattle.

Address reprint requests to Dr. Burke at the Department of Medical History and Ethics, Box 357120, University of Washington, 1959 NE Pacific, Rm. A204, Seattle, WA 98195, or at wburke@u.washington.edu.

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