Atrial fibrillation is a common cardiac arrhythmia whose mostserious clinical consequence is stroke. Described in pathologicalstudies in the 1940s, uncoordinated atrial contractions resultin sluggish blood flow and the formation of thrombus in theatrial appendage: "The immobility of the auricular walls makesthem defenceless against thrombotic deposits, as a horse shouldbe against flies without his cutaneous muscles"1 (see Figure).The stasis-precipitated thrombi lead to emboli that are distributedaccording to cardiac output, but emboli to the brain accountfor about 80 percent of symptomatic emboli. Because they arelarger on average than emboli of valvular . . . [Full Text of this Article]
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From the Department of Medicine, Division of Neurology, University of Texas Health Science Center, San Antonio.
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