Hypertrophic cardiomyopathy has fascinated clinicians and clinicalinvestigators since its initial description almost 50 yearsago because of the unique physical findings, often bizarre electrocardiographicaspects, unusual shape of the left ventricle on contrast ventriculography,typically asymmetric distribution of hypertrophy on echocardiography,and abnormal filling of the left ventricle in diastole. Someaspects of the disease have generated considerable controversy,such as the mechanism (and even the existence) of dynamic intraventricularpressure gradients in some patients.
No less contentious is the debate about how clinicians mightpredict the most feared complication of this disease: suddendeath. Although clinical predictors of . . . [Full Text of this Article]
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From the National Heart, Lung, and Blood Institute, Bethesda, Md.
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