FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 349:1056-1063 September 11, 2003 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

This Journal feature begins with a case vignette highlighting a common clinical problem. Evidence supporting various strategies is then presented, followed by a review of formal guidelines, when they exist. The article ends with the author's clinical recommendations.

A 72-year-old, college-educated woman comes in for the evaluation of mild memory loss that has been gradually progressing for the past two years. The patient lives alone, drives her own car, and manages her own finances, although she has recently made some errors in her checkbook. She also forgot the location of her car in a mall parking lot for two hours. . . . [Full Text of this Article]

The Clinical Problem

Definitions of Dementia, Mild Cognitive Impairment, and Normal Aging

Subjective Symptoms Related to Memory

Strategies and Evidence

Diagnosis

Treatment of Primary Symptoms

            Nonpharmacologic Management, Education, and Support

            Pharmacologic Management

Treatment of Secondary Symptoms

Areas of Uncertainty

Guidelines

Conclusions and Recommendations

Source Information

From the Institute for Brain Aging and Dementia and the Departments of Neurology and Neurobiology and Behavior, University of California, Irvine.

Address reprint requests to Dr. Kawas at the University of California, Irvine, 1121 Gillespie, Irvine, CA 92697-4540, or at ckawas@uci.edu.

Related Letters:

Early Alzheimer's Disease
Clarfield A. M., Ruiz-Ruiz F. J., Hausner R. S., Mahmoud R., Greenspan A., O'Dwyer C., O'Shea D., Kawas C. H.
Extract | Full Text | PDF  
N Engl J Med 2004; 350:80-82, Jan 1, 2004. Correspondence

This article has been cited by other articles:

• Wilkinson, H., Weaks, D. (2008). Editorial: Hearing the voices in the policy--practice--research nexus: The importance of the knowledge exchange process for people with dementia. Dementia 7: 427-431  
• LoConte, N. K., Gleason, C. E., Gunter-Hunt, G., Carlsson, C. M., Siebers, M. (2008). Standardized Note Template Improves Screening of Firearm Access and Driving Among Veterans With Dementia. AM J ALZHEIMERS DIS OTHER DEMEN 23: 313-318 [Abstract]  
• Thomas, P., Fenech, M. (2008). Chromosome 17 and 21 aneuploidy in buccal cells is increased with ageing and in Alzheimer's disease. Mutagenesis 23: 57-65 [Abstract] [Full Text]  
• Eichler, K., Scrabal, C., Steurer, J., Mann, E. (2007). Preventive health risk appraisal for older people and impact on GPs' patient management: a prospective study. Fam Pract 24: 604-609 [Abstract] [Full Text]  
• Thomas, P., Hecker, J., Faunt, J., Fenech, M. (2007). Buccal micronucleus cytome biomarkers may be associated with Alzheimer's disease. Mutagenesis 22: 371-379 [Abstract] [Full Text]  
• Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., Sabatini, B. L. (2007). Natural Oligomers of the Alzheimer Amyloid-{beta} Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway. J. Neurosci. 27: 2866-2875 [Abstract] [Full Text]  
• Thomas, P., Fenech, M. (2007). A review of genome mutation and Alzheimer's disease. Mutagenesis 22: 15-33 [Abstract] [Full Text]  
• Lin, S.-J., Kuo, S.-C., Yang, Y.-H. K. (2006). Appeals System and Its Outcomes in National Health Insurance in Taiwan. The Annals of Pharmacotherapy 40: 506-511 [Abstract] [Full Text]  
• Mooijaart, S. P, Gussekloo, J., Frolich, M., Jolles, J., Stott, D. J, Westendorp, R. G., de Craen, A. J. (2005). Homocysteine, vitamin B-12, and folic acid and the risk of cognitive decline in old age: the Leiden 85-Plus Study. Am. J. Clin. Nutr. 82: 866-871 [Abstract] [Full Text]  
• Cummings, J. L. (2004). Alzheimer's Disease. NEJM 351: 56-67 [Full Text]  
• Adelman, R. D., Greene, M. G., Friedmann, E. (2004). Discussions about cognitive impairment in first medical visits: Older patients' perceptions and preferences. AM J ALZHEIMERS DIS OTHER DEMEN 19: 233-238 [Abstract]  
• Jhamandas, J. H., MacTavish, D. (2004). Antagonist of the Amylin Receptor Blocks {beta}-Amyloid Toxicity in Rat Cholinergic Basal Forebrain Neurons. J. Neurosci. 24: 5579-5584 [Abstract] [Full Text]  
• Gill, S. S., Mamdani, M., Rochon, P. A. (2004). Management of Overactive Bladder. NEJM 350: 2213-2213 [Full Text]  
• Ajilore, O. A., Kumar, A. (2004). Delirium and Dementia. Focus 2: 210-220 [Abstract] [Full Text]  
• Clarfield, A. M., Ruiz-Ruiz, F. J., Hausner, R. S., Mahmoud, R., Greenspan, A., O'Dwyer, C., O'Shea, D., Kawas, C. H. (2004). Early Alzheimer's Disease. NEJM 350: 80-82 [Full Text]