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Volume 349:1090 September 11, 2003 Number 11
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Aromatase Inhibitors in Breast Cancer

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by Smith, I. E.
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To the Editor: Smith and Dowsett (June 12 issue)1 do not mention the possible abuse of aromatase inhibitors by bodybuilders and others who may misuse anabolic steroids. Misuse of testosterone and other androgens by male bodybuilders may be associated with the development of gynecomastia due to the synthesis of estrogens from exogenous androgen precursors.2

Tamoxifen and other estrogen-receptor blockers, as well as the aromatase inhibitor aminoglutethimide, may be used to prevent gynecomastia associated with androgen misuse.3,4 A possible additional benefit of aminoglutethimide is that it may block the cortisol response to exercise. The use of aminoglutethimide in this context would . . . [Full Text of this Article]



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