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Volume 349:1294 September 25, 2003 Number 13
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Mast Cells and the Mediation of T-Cell Recruitment in Arthritis

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by Woolley, D. E.
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To the Editor: The article by Woolley (April 24 issue)1 is timely but incomplete. Not mentioned are findings about the role of mast cells in the local recruitment of effector T cells in arthritis. Studies of T-cell–mediated contact and delayed-type hypersensitivity in mice have shown that antibodies have a crucial initiating role through the activation of mast cells by complement C5a. Mast cells release vasoactive mediators, such as tumor necrosis factor {alpha}, which stimulate the local endothelium to optimize the local recruitment of T cells.2,3,4 Thus, soon after immunization, B-1 B cells produce antigen-specific IgM antibodies, and later, B-2 cells . . . [Full Text of this Article]



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