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Previous Volume 349:1381-1383 October 2, 2003 Number 14 Next

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On October 3, 1953 — almost exactly half a century ago — Rupert E. Billingham, Peter B. Medawar, and I published a paper in Nature titled "‘Actively Acquired Tolerance’ of Foreign Cells."¹ Medawar was the senior author, Billingham was his research fellow, and I was Medawar's postgraduate student. I was about to begin the third and final year of my Ph.D. studies. Immunologic tolerance formed an important, but not the only, part of my thesis. The eight-page preliminary paper in Nature firmly established the basis of immunologic tolerance and, in part, its mechanism. Seven years later, it led to the . . . [Full Text of this Article]

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