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Previous Volume 349:1387-1388 October 2, 2003 Number 14 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: I believe that Table 2 of the article by Nabel (July 3 issue)¹ gives misleading information concerning apparent mineralocorticoid excess: this disease is said to be due to mutations in the gene encoding 11-hydroxylase, but in fact, mutations in this gene cause one form of congenital adrenal hyperplasia.² Apparent mineralocorticoid excess is caused by inactivating mutations in the gene encoding 11-hydroxysteroid dehydrogenase type 2,³ the microsomal enzyme that metabolizes cortisol into its receptor-inactive keto form, cortisone, in sodium-transporting epithelia, such as the kidney, and thus protects the nonselective mineralocorticoid receptor from occupation by cortisol itself. . . . [Full Text of this Article]

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