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Volume 349:1575 October 16, 2003 Number 16
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The Solitary Pulmonary Nodule

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 by Ost, D.
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To the Editor: In their Clinical Practice article, Ost and colleagues (June 19 issue)1 do not specifically address coccidioidomycosis. In areas where this disease is endemic, the percentage of pulmonary nodules due to coccidioidomycosis is nearly 30 percent.2 Many such nodules are noncalcified and larger than 3 cm in diameter, suggesting that such patients are at high risk for neoplasm. In most cases, the results of coccidioidal serologic tests are negative and imaging techniques are unhelpful, leading to the use of invasive techniques to establish the diagnosis. Fine-needle aspiration is diagnostic in only about 50 percent of cases of coccidioidal . . . [Full Text of this Article]




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