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There was a time when it could be said, with some confidence, that "now that infectious diseases have been controlled by antibiotics, we can turn our attention to more interesting problems" (medical grand rounds, Peter Bent Brigham Hospital, 1955) and that "if any more infectious diseases specialists were trained, they would be culturing one another" (R.G. Petersdorf, Annual Meeting of the Infectious Diseases Society of America, 1985). Those good times are gone forever.
After the temporary success of antimicrobial drugs against infectious diseases, the balance has now tilted in favor of the microbes. The genetic plasticity of microbes, along with
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