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Volume 349:1774-1776 October 30, 2003 Number 18
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Microsatellite Instability in Colon Cancer

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by Ribic, C. M.
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To the Editor: Ribic et al. (July 17 issue)1 investigated microsatellite instability as a predictor of a benefit from adjuvant chemotherapy in patients with stage II or stage III colon cancer, and their findings confirm that microsatellite instability portends a better prognosis than microsatellite-stable cancer.1,2,3 However, this research differs from that of Elsaleh et al., in which patients whose stage III colorectal cancer demonstrated microsatellite instability derived the greatest benefit from adjuvant chemotherapy.4 In contrast, Ribic et al. found that patients with microsatellite instability did not benefit from adjuvant chemotherapy and may have been harmed by it (P=0.01). We wish . . . [Full Text of this Article]



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