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Correspondence
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Volume 349:192-193 July 10, 2003 Number 2
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Is Luteinizing Hormone–Releasing Hormone Agonist Justified in Short Adolescents?

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 by Lee, M. M.
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 by Yanovski, J. A.
-PubMed Citation
To the Editor: In their article on the effects of luteinizing hormone–releasing hormone agonist in the treatment of adolescents with short stature, Yanovski et al. (March 6 issue)1 predict that the deficit in bone mineral density will not be recovered, as has been shown in other interruptions of puberty and in constitutional delay.2 Constitutional delay, however, is generally regarded as a developmental variation. Data on bone density after constitutional delay are sparse and contradictory; data from the cited series2 conflict with data from two others,3,4 although all three were appropriately designed. Stating that a deficit in bone mineral density follows . . . [Full Text of this Article]


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