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Previous Volume 349:193-194 July 10, 2003 Number 2 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: We disagree with Nussbaum and Ellis's statement that gene variations other than the APOE 4 allele are elusive in the nonfamilial form of Alzheimer's disease (April 3 issue).¹ The candidate-gene approach has already identified genes with a potential role in the etiology of the disease.² In addition, over the past 15 years, a number of inflammatory mediators have been observed in the brain affected by Alzheimer's disease. In this disease, inflammation clearly occurs in pathologically vulnerable regions of the brain and may influence other neuropathologic hallmarks of the disease, although it is unclear whether altered immune responses . . . [Full Text of this Article]

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