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Volume 349:2183-2184 December 4, 2003 Number 23 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Hematopoietic stem-cell transplantation is an effective but toxic therapy for a number of life-threatening diseases, especially hematologic cancers. The principal complication of allogeneic stem-cell transplantation (the transplantation of grafts from genetically different donors) is graft-versus-host disease (GVHD), which can occur despite aggressive immunosuppressive prophylaxis and even when the donor is a "perfectly" matched (HLA-identical) sibling. The complex pathophysiology of GVHD fundamentally depends on interactions between antigen-presenting cells of the recipient and mature T cells of the donor (see Figure). A substantial body of research in animal models has uncovered the contribution of cytokines to the inflammation and tissue damage . . . [Full Text of this Article]

Source Information

From the Blood and Marrow Transplant Program, University of Michigan Comprehensive Cancer Center (K.R.C., J.L.M.F.); and the Departments of Internal Medicine (J.L.M.F.) and Pediatrics (K.R.C., J.L.M.F.), University of Michigan Medical School — both in Ann Arbor.

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