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Background Polymorphisms in cytokine genes can influence immune responses, inflammation, and tissue injury and may affect the outcome of hematopoietic stem-cell transplantation.
Methods We analyzed single-nucleotide polymorphisms in the genes for interleukin-1
Results The recipient's IL10 promoter region genotype was significantly associated with the risk of acute GVHD in the first cohort. Analysis of all 993 transplant recipients showed that, as compared with the C/C genotype, the IL10 –592A/A genotype was associated with a decreased risk of grade III or IV acute GVHD (hazard ratio, 0.4; 95 percent confidence interval, 0.2 to 0.9; P=0.02) and death in remission (hazard ratio, 0.6; 95 percent confidence interval, 0.3 to 1.0; P=0.05). A haplotype analysis showed that the IL10 –592A allele was a specific marker for a promoter haplotype, T-C-A-T-A, defined by five polymorphisms at positions –3575, –2763, –1082, –819, and –592, respectively.
Conclusions Among recipients of hematopoietic cells from an HLA-identical sibling, the IL10 –592A allele is a marker of a favorable outcome after transplantation.
, interleukin-1–receptor antagonist, interleukin-6, interleukin-10 (IL10), and tumor necrosis factor 
in 570 transplant recipients and their HLA-identical sibling donors. Genotypes were tested for an association with graft-versus-host disease (GVHD) by multivariable analysis. A second cohort of 423 transplant recipients was independently analyzed for the genotype associations identified in the first cohort.
Source Information
From the Fred Hutchinson Cancer Research Center (M.-T.L., B.S., P.J.M., T.G., J.A.H.) and the University of Washington, School of Medicine (P.J.M., J.A.H.) — both in Seattle; and the Department of Medical Genetics, National Taiwan University Hospital (L.-H.T., P.-J.C.), and the College of Medicine, Graduate Institutes of Clinical Medicine (P.-J.C.), and Cancer Research Center (M.-T.L.), National Taiwan University — both in Taipei, Taiwan.
Address reprint requests to Dr. Hansen at the Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., D2-100, P.O. Box 19024, Seattle, WA 98109-1024, or at jhansen{at}fhcrc.org.
Related Letters:
Interleukin-10 and Graft-versus-Host Disease
Kida Y., Lin M.-T., Martin P. J., Hansen J. A.
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N Engl J Med 2004;
350:1361-1362, Mar 25, 2004.
Correspondence
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