The prostate is a complex organ composed of epithelial cellsand fibromuscular stroma. Benign prostatic hyperplasia is atrue hyperplastic process, with an increase in the number ofcells arising initially in the transition zone of the gland.Complex stromal–epithelial interactions lead to benignprostatic hyperplasia in 50 percent of men by the age of 50years. This process requires testicular androgens and progresseswith age. Aging is accompanied by an increase in symptoms ofbladder obstruction or irritation attributable to benign prostatichyperplasia. A prospective study showed that 24 percent of menwith moderate symptoms of benign prostatic hyperplasia . . . [Full Text of this Article]
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From the Department of Urology, Weill Medical College of Cornell University, New York.
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