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Correspondence
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Volume 349:2563-2565 December 25, 2003 Number 26
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Chronic Renal Failure after Transplantation of a Nonrenal Organ

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by Ojo, A. O.
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To the Editor: Ojo et al. (Sept. 4 issue)1 describe a growing problem: renal failure after nonrenal transplantation. However, the authors use a calculated glomerular filtration rate (from the Modification of Diet in Renal Disease [MDRD] study2), which has not been validated in patients with liver failure. We compared the measured glomerular filtration rate with the calculated glomerular filtration rate in more than 1300 patients with liver failure.3 The MDRD equation had an r value of 0.67 and an r2 value of only 0.452. Therefore, using a calculated glomerular filtration rate in this population may be unwarranted. Our data . . . [Full Text of this Article]



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