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Volume 349:2567-2568 December 25, 2003 Number 26
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Office-Based Treatment of Opiate Addiction

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by Fudala, P. J.
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To the Editor: The study by Fudala et al. (Sept. 4 issue)1 may have underestimated the percentage of urine specimens that were positive for opioids in both groups. Urinary drug testing was performed with the use of an immunoassay and did not include gas chromatography and mass spectrometry. If the purpose of testing is to find out whether unprescribed or illicit opioids are being used, gas chromatography–mass spectrometry is the most specific test for identifying individual drugs or their metabolites.2 Routine immunoassay is sensitive for natural opiates such as morphine (a metabolite of heroin) and codeine but has a low . . . [Full Text of this Article]



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