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Volume 349:2570 December 25, 2003 Number 26
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Gentamicin and CFTR

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by Wilschanski, M.
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To the Editor: Wilschanski et al. (Oct. 9 issue)1 report that full-length cystic fibrosis transmembrane conductance regulator (CFTR) protein was expressed more effectively on the surface of nasal epithelial cells after gentamicin treatment than after placebo in patients with cystic fibrosis who had premature stop codons. Bedwell et al. observed that the expression of CFTR at the apical plasma membrane was restored after administration of the aminoglycoside antibiotic G-418 and that further mobilization of CFTR at this location was promoted by cyclic AMP (cAMP) stimulation.2 CFTR is normally recycled between the apical plasma membrane and an early endosomal compartment.3 The . . . [Full Text of this Article]



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