It seems that death and taxes are not the only sure things inlife anymore. Now, all adults in late middle age must also confronta complex individualized calculation of the risks and benefitsof long-term pharmacologic manipulation of the sex hormones.
Women and their doctors learned this lesson last summer, whena large study of postmenopausal estrogen and progesterone supplementationwas stopped prematurely, with the finding that the hormonesrelieved menopausal symptoms and lowered the risks of hip fracturesand colon cancer but did so at the price of increased risksof myocardial infarction, stroke, and breast cancer.
From St. Luke'sRoosevelt Hospital Center, New York.
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N Engl J Med 2003;
349:1569-1572, Oct 16, 2003.
Correspondence
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