This Journal feature begins with a case vignette highlightinga common clinical problem. Evidence supporting various strategiesis then presented, followed by a review of formal guidelines,when they exist. The article ends with the author's clinicalrecommendations.
A 28-year-old woman telephones her physician to report dysuriaand urinary urgency during the preceding three days. She hashad several previous urinary tract infections, including threeduring the past year. She is otherwise healthy, takes no medications,and is sexually active, using spermicide-coated condoms forcontraception. She says she does not have fever, chills, vaginaldischarge, or flank pain. How should . . . [Full Text of this Article]
The Clinical Problem
Strategies and Evidence
Clinical History
Risk Factors
Diagnostic Tests
Treatment
Uncomplicated Acute Pyelonephritis
Follow-up and Evaluation
Recurrent Infections
Areas of Uncertainty
Are There Reliable Predictors of the Failure of Treatment for Acute Cystitis?
What is the Optimal Therapy for Acute Uncomplicated Cystitis?
Is Exogenous Estrogen Effective in Preventing Recurrent Urinary Tract Infections in Postmenopausal Women?
Guidelines
Conclusions and Recommendations
Source Information
From the Northwest Health Services Research and Development Center of Excellence, Veterans Affairs (VA) Puget Sound Health Care System, and the University of Washington both in Seattle.
Address reprint requests to Dr. Fihn at the Northwest Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System (152), 1660 S. Columbian Way, Seattle WA 98108, or at sfihn@u.washington.edu.
This article has been cited by other articles:
McIsaac, W. J., Moineddin, R., Ross, S.
(2007). Validation of a Decision Aid to Assist Physicians in Reducing Unnecessary Antibiotic Drug Use for Acute Cystitis. Arch Intern Med
167: 2201-2206
[Abstract][Full Text]
Kahan, N. R, Chinitz, D. P, Waitman, D.-A., Dushnitzky, D., Kahan, E., Shapiro, M.
(2006). Empiric Treatment of Uncomplicated Urinary Tract Infection with Fluoroquinolones in Older Women in Israel: Another Lost Treatment Option?. The Annals of Pharmacotherapy
40: 2223-2227
[Abstract][Full Text]
Piccoli, G. B., Colla, L., Mezza, E., Burdese, M., Cammarota, T., Piccoli, G.
(2006). Oestroprogestagens and severe acute pyelonephritis: a casual or causal association?. Nephrol Dial Transplant
21: 2337-2337
[Full Text]
Nys, S., van Merode, T., Bartelds, A. I. M., Stobberingh, E. E.
(2006). Urinary tract infections in general practice patients: diagnostic tests versus bacteriological culture. J Antimicrob Chemother
57: 955-958
[Abstract][Full Text]
Kallen, A. J., Welch, H. G., Sirovich, B. E.
(2006). Current antibiotic therapy for isolated urinary tract infections in women.. Arch Intern Med
166: 635-639
[Abstract][Full Text]
Galatti, L., Sessa, A., Mazzaglia, G., Pecchioli, S., Rossi, A., Cricelli, C., Schito, G. C., Nicoletti, G., Caputi, A. P.
(2006). Antibiotic prescribing for acute and recurrent cystitis in primary care: a 4 year descriptive study. J Antimicrob Chemother
57: 551-556
[Abstract][Full Text]
Gilbert, D. N.
(2006). Urinary Tract Infections in Patients with Chronic Renal Insufficiency. CJASN
1: 327-331
[Abstract][Full Text]
Sheffield, J. S., Cunningham, F. G.
(2005). Urinary Tract Infection in Women. Obstet Gynecol
106: 1085-1092
[Abstract][Full Text]
Lindgren, P. K., Marcusson, L. L., Sandvang, D., Frimodt-Moller, N., Hughes, D.
(2005). Biological Cost of Single and Multiple Norfloxacin Resistance Mutations in Escherichia coli Implicated in Urinary Tract Infections. Antimicrob. Agents Chemother.
49: 2343-2351
[Abstract][Full Text]
Brown, J. S., Wessells, H., Chancellor, M. B., Howards, S. S., Stamm, W. E., Stapleton, A. E., Steers, W. D., Van Den Eeden, S. K., McVary, K. T.
(2005). Urologic Complications of Diabetes. Diabetes Care
28: 177-185
[Full Text]
Talan, D. A., Hoey, R., Probst, F., Fihn, S. D.
(2003). Urinary Tract Infection. NEJM
349: 1674-1676
[Full Text]