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Volume 349:398-400 July 24, 2003 Number 4
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Low-Intensity Warfarin Therapy for the Prevention of Recurrent Venous Thromboembolism

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by Ridker, P. M
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To the Editor: We have two major concerns regarding the report by Ridker et al. on low-intensity warfarin therapy (April 10 issue).1 First, in this study, low-dose, long-term warfarin therapy resulted in a relative reduction in the risk of recurrent venous thromboembolism of 64 percent as compared with placebo. However, data from another trial show that full-dose warfarin is more effective than low-dose warfarin.2 Indeed, full-dose warfarin therapy has resulted in a relative reduction in risk of 90 percent.3 In addition, the risk of bleeding is similar with the two intensities of warfarin treatment (Table 1). Hence, the . . . [Full Text of this Article]



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