FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 349:402-405 July 24, 2003 Number 4 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Schechter, A. N. PubMed Citation

To the Editor: The article by Schechter and Gladwin (April 10 issue)¹ is flawed by a fundamental error. The conclusions that the authors draw from reports of measured S-nitrosohemoglobin levels and decomposition rates are not disciplined by quantitative standards of efficacy: "lower" does not imply "too low," nor does "rapid" imply "too rapid."

The authors cite studies in which S-nitrosohemoglobin levels (approximately 50 nmol per liter) are lower than those in previous reports (micromolar levels). They fail to mention, however, that Pawloski et al. demonstrated bioactivity of red cells with S-nitrosohemoglobin at 50 nmol per liter,² and McMahon et al. . . . [Full Text of this Article]

This article has been cited by other articles:

• Gladwin, M. T. (2008). Evidence Mounts That Nitrite Contributes to Hypoxic Vasodilation in the Human Circulation. Circulation 117: 594-597 [Full Text]  
• Mammen, P. P.A., Shelton, J. M., Ye, Q., Kanatous, S. B., McGrath, A. J., Richardson, J. A., Garry, D. J. (2006). Cytoglobin Is a Stress-responsive Hemoprotein Expressed in the Developing and Adult Brain. J. Histochem. Cytochem. 54: 1349-1361 [Abstract] [Full Text]  
• Aldini, G., Pirrone, F., Albertini, M., Orioli, M., Piccoli, A., Mazzola, S., Clement, M. G., Carini, M. (2006). Electron Spin Resonance and Chemiluminescence Analyses to Elucidate the Vasodilating Mechanism of Sodium Nitroprusside. Mol. Pharmacol. 70: 1672-1680 [Abstract] [Full Text]  
• Gladwin, M. T., Raat, N. J. H., Shiva, S., Dezfulian, C., Hogg, N., Kim-Shapiro, D. B., Patel, R. P. (2006). Nitrite as a vascular endocrine nitric oxide reservoir that contributes to hypoxic signaling, cytoprotection, and vasodilation. Am. J. Physiol. Heart Circ. Physiol. 291: H2026-H2035 [Abstract] [Full Text]  
• Atkins, J. L., Day, B. W., Handrigan, M. T., Zhang, Z., Pamnani, M. B., Gorbunov, N. V. (2006). Brisk production of nitric oxide and associated formation of S-nitrosothiols in early hemorrhage. J. Appl. Physiol. 100: 1267-1277 [Abstract] [Full Text]  
• Gladwin, M. T. (2005). Hemoglobin as a Nitrite Reductase Regulating Red Cell-Dependent Hypoxic Vasodilation. Am. J. Respir. Cell Mol. Bio. 32: 363-366 [Full Text]  
• Gladwin, M. T., Schechter, A. N. (2004). NO Contest: Nitrite Versus S-Nitroso-Hemoglobin. Circ. Res. 94: 851-855 [Full Text]