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Previous Volume 349:410 July 24, 2003 Number 4 Next

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(Oxford Monographs on Medical Genetics.) Second edition. Edited by Richard A. King, Jerome I. Rotter, and Arno G. Motulsky. 1076 pp., illustrated. New York, Oxford University Press, 2002. $195. ISBN 0-19-512582-7.

The aim of this new edition of The Genetic Basis of Common Diseases is to present the state of the art in the understanding of the genetics of specific illnesses. A disease is regarded as common if its prevalence is higher than 1 in 1000. The etiology of most common diseases is multifactorial, but some mendelian conditions have a high prevalence (e.g., hereditary hemochromatosis and the genetic predisposition toward breast or colorectal cancer). The same holds true for chromosomal anomalies. In this textbook, many common multifactorial diseases are studied. There is no chapter devoted to congenital malformations, which represent a . . . [Full Text of this Article]

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