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Correction to Crespo et al., N Engl J Med 348(18):1764-1775 May 1, 2003.

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Volume 349:506-507 July 31, 2003 Number 5
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ZAP-70 in Chronic Lymphocytic Leukemia

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by Crespo, M.
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To the Editor: Crespo et al. (May 1 issue)1 present informative data on ZAP-70 as a surrogate prognostic marker for chronic lymphocytic leukemia (CLL). The patients in their study had heterogeneous backgrounds and may have been treated by different treatment strategies according to their age and disease status. Elderly patients with advanced or refractory CLL may have received less intensive treatment than others, leading to a poorer prognosis. Because treatments differ greatly in their effects on overall survival, there may have been a selection bias in the study. The authors have not provided sufficient information on these variables. Clinicians will . . . [Full Text of this Article]



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