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Correspondence
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Volume 349:508-509 July 31, 2003 Number 5
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Profile of Specific Antibodies to the SARS-Associated Coronavirus

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To the Editor: A novel coronavirus called the severe acute respiratory syndrome (SARS)–associated coronavirus (CoV) has been identified as the causal agent of SARS.1,2,3 To understand the humoral immunity to this virus, we studied the profile of IgM and IgG antibody responses to SARS-CoV. IgM and IgG antibodies were analyzed by an indirect enzyme-linked immunosorbent assay in 20 patients with SARS from week 1 of their illness to week 12 and in 103 healthy contacts.

All 20 patients tested negative for IgM and IgG at week 1 after the onset of symptoms. Of these patients, 16 tested positive for IgM . . . [Full Text of this Article]


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