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Previous Volume 349:603-605 August 7, 2003 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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The technique of the sentinel-node biopsy has reoriented our understanding of the dynamics between a solid tumor and its associated lymphatic collection system.^1,2,3,4 Moreover, the sentinel-node biopsy is an excellent way of lessening the side effects of surgery and of improving the accuracy of regional node resection. Since this method is such a fundamental change in surgical oncology, it is important to design clinical trials that will give a clear answer to the following question: Is a reduction in survival the price of limited and more accurate surgery?

The design of a clinical trial starts not with a formal application . . . [Full Text of this Article]

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From the Departments of Surgery (D.K.) and Medical Biostatistics (T.A.), Vermont Cancer Center, University of Vermont College of Medicine, Burlington.

Related Letters:

Sentinel-Node Biopsy in Breast Cancer
Badwe R. A., Thorat M. A., Parmar V. V., De Salvo G. L., Del Bianco P., Zavagno G., Munster A. M., McMasters K. M., Veronesi U., Maisonneuve P., Krag D., Ashikaga T.
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N Engl J Med 2003; 349:1968-1971, Nov 13, 2003. Correspondence

This article has been cited by other articles:

• Badwe, R. A., Thorat, M. A., Parmar, V. V., De Salvo, G. L., Del Bianco, P., Zavagno, G., Munster, A. M., McMasters, K. M., Veronesi, U., Maisonneuve, P., Krag, D., Ashikaga, T. (2003). Sentinel-Node Biopsy in Breast Cancer. NEJM 349: 1968-1971 [Full Text]  
• (2003). Sentinel-Node Biopsy: As Accurate as Axillary Dissection. JWatch Women's Health 2003: 7-7 [Full Text]  
• (2003). Outcomes After Sentinel-Node Biopsy in Breast Cancer. JWatch General 2003: 3-3 [Full Text]