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Previous Volume 349:606-609 August 7, 2003 Number 6 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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To the Editor: Branson et al. (March 20 issue)¹ found DNA sequence changes in the melanocortin 4 receptor (MC4R) gene in 24 of 469 severely obese subjects and confirmed binge eating in all the carriers examined. Of the 25 sequence changes identified, 11 (44 percent) were the Val103Ile change that my colleagues and I reported originally as a sequence variant that was not associated with obesity or obesity-related phenotypes.² The notion that the Val103Ile change represents a variant of little physiologic significance has been supported by many functional and genetic studies.³ The only exception is a study that . . . [Full Text of this Article]

This article has been cited by other articles:

• Tao, Y.-X., Segaloff, D. L. (2005). Functional Analyses of Melanocortin-4 Receptor Mutations Identified from Patients with Binge Eating Disorder and Nonobese or Obese Subjects. J. Clin. Endocrinol. Metab. 90: 5632-5638 [Abstract] [Full Text]