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Volume 349:627-628 August 14, 2003 Number 7 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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I was a brand-new fellow in pediatric hematology–oncology, in July 1963, when I first cared for a child with acute leukemia. By then, with chemotherapy we were able to induce temporary remissions in many patients, but none of them were cured.

At that time, the immediate clinical concerns arose mainly from thrombocytopenia and neutropenia. Life-threatening hemorrhage was a constant worry in patients with newly diagnosed or relapsed disease, and platelet transfusions were not yet widely available. Fatal intracranial or gastrointestinal hemorrhage was distressingly common. Infection, mainly by gram-negative organisms, threatened all patients who were not in remission. The most dreaded . . . [Full Text of this Article]

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From Simone Consulting, Dunwoody, Ga.

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