FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 349:733-742 August 21, 2003 Number 8 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Editorial by Jacobs, A. K. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background For the treatment of myocardial infarction with ST-segment elevation, primary angioplasty is considered superior to fibrinolysis for patients who are admitted to hospitals with angioplasty facilities. Whether this benefit is maintained for patients who require transportation from a community hospital to a center where invasive treatment is available is uncertain.

Methods We randomly assigned 1572 patients with acute myocardial infarction to treatment with angioplasty or accelerated treatment with intravenous alteplase; 1129 patients were enrolled at 24 referral hospitals and 443 patients at 5 invasive-treatment centers. The primary study end point was a composite of death, clinical evidence of reinfarction, or disabling stroke at 30 days.

Results Among patients who underwent randomization at referral hospitals, the primary end point was reached in 8.5 percent of the patients in the angioplasty group, as compared with 14.2 percent of those in the fibrinolysis group (P=0.002). The results were similar among patients who were enrolled at invasive-treatment centers: 6.7 percent of the patients in the angioplasty group reached the primary end point, as compared with 12.3 percent in the fibrinolysis group (P=0.05). Among all patients, the better outcome after angioplasty was driven primarily by a reduction in the rate of reinfarction (1.6 percent in the angioplasty group vs. 6.3 percent in the fibrinolysis group, P<0.001); no significant differences were observed in the rate of death (6.6 percent vs. 7.8 percent, P=0.35) or the rate of stroke (1.1 percent vs. 2.0 percent, P=0.15). Ninety-six percent of patients were transferred from referral hospitals to an invasive-treatment center within two hours.

Conclusions A strategy for reperfusion involving the transfer of patients to an invasive-treatment center for primary angioplasty is superior to on-site fibrinolysis, provided that the transfer takes two hours or less.

Source Information

From the Departments of Cardiology at Skejby Hospital, Aarhus University Hospital, Aarhus (H.R.A., T.T.N., L.T., L.R.K.); Aalborg University Hospital, Aalborg (K.R., A.B.V.); Rigshospitalet University Hospital, Copenhagen (H.K., J.K.M., P.G.); Odense University Hospital, Odense (P.T., T.H.); and the Gentofte Hospital, Hellerup (U.A.); the Departments of Medicine at Hilleroed Hospital, Hilleroed (F.P.); Randers Hospital, Randers (P.L.); Aarhus County Hospital and Aarhus University Hospital, Aarhus (S.E.H.); and Horsens Hospital, Horsens (E.V.); the Department of Cardiothoracic Surgery, Gentofte Hospital, Hellerup (H.K.K.); and UNI-C, Danish Information Technology Centre for Education and Research, Aarhus (L.S.M.) — all in Denmark.

Address reprint requests to Dr. Andersen at the Department of Cardiology, Skejby Hospital, Aarhus University Hospital, DK-8200 Aarhus N, Denmark, or at henning.rud.andersen{at}iekf.au.dk.

Full Text of this Article

Related Letters:

Coronary Angioplasty versus Fibrinolytic Therapy in Acute Myocardial Infarction
Channer K. S., Armstrong P. W., Antman E. M., Zaman A. G., Andersen H. R., Nielsen T. T.
Extract | Full Text | PDF  
N Engl J Med 2003; 349:2167-2169, Nov 27, 2003. Correspondence

This article has been cited by other articles:

• Hvelplund, A., Galatius, S., Madsen, M., Rasmussen, J. N., Rasmussen, S., Madsen, J. K., Sand, N. P.R., Tilsted, H.-H., Thayssen, P., Sindby, E., Hojbjerg, S., Abildstrom, S. Z. (2009). Women with acute coronary syndrome are less invasively examined and subsequently less treated than men. Eur Heart J 0: ehp493v1-ehp493 [Abstract] [Full Text]  
• Widimsky, P., Wijns, W., Fajadet, J., de Belder, M., Knot, J., Aaberge, L., Andrikopoulos, G., Baz, J. A., Betriu, A., Claeys, M., Danchin, N., Djambazov, S., Erne, P., Hartikainen, J., Huber, K., Kala, P., Klinceva, M., Kristensen, S. D., Ludman, P., Ferre, J. M., Merkely, B., Milicic, D., Morais, J., Noc, M., Opolski, G., Ostojic, M., Radovanovic, D., De Servi, S., Stenestrand, U., Studencan, M., Tubaro, M., Vasiljevic, Z., Weidinger, F., Witkowski, A., Zeymer, U., on behalf of the European Association for Percutan, (2009). Reperfusion therapy for ST elevation acute myocardial infarction in Europe: description of the current situation in 30 countries. Eur Heart J 0: ehp492v1-ehp492 [Abstract] [Full Text]  
• Sejersten, M., Valeur, N., Grande, P., Nielsen, T. T., Clemmensen, P., for the DANAMI-2 Investigators, (2009). Long-term prognostic value of ST-segment resolution in patients treated with fibrinolysis or primary percutaneous coronary intervention results from the DANAMI-2 (DANish trial in acute myocardial infarction-2).. J Am Coll Cardiol 54: 1763-1769 [Abstract] [Full Text]  
• Prgomet, M., Georgiou, A., Westbrook, J. I. (2009). The Impact of Mobile Handheld Technology on Hospital Physicians' Work Practices and Patient Care: A Systematic Review. J. Am. Med. Inform. Assoc. 16: 792-801 [Abstract] [Full Text]  
• Isakov, A. (2009). Urgent air-medical transport: Right patient, place and time. CMAJ 181: 569-570 [Full Text]  
• Danchin, N. (2009). Systems of Care for ST-Segment Elevation Myocardial Infarction: Impact of Different Models on Clinical Outcomes. J Am Coll Cardiol Intv 2: 901-908 [Abstract] [Full Text]  
• Pedersen, S., Galatius, S., Mogelvang, R., Davidsen, U., Galloe, A., Abildstrom, S. Z., Abildgaard, U., Hansen, P. R., Bech, J., Iversen, A., Jorgensen, E., Kelbaek, H., Saunamaki, K., Madsen, J. K., Jensen, J. S. (2009). Long-Term Prognosis in an ST-Segment Elevation Myocardial Infarction Population Treated With Routine Primary Percutaneous Coronary Intervention: From Clinical Trial to Real-Life Experience. Circ Cardiovasc Interv 2: 392-400 [Abstract] [Full Text]  
• Wang, T. Y., Fonarow, G. C., Hernandez, A. F., Liang, L., Ellrodt, G., Nallamothu, B. K., Shah, B. R., Cannon, C. P., Peterson, E. D. (2009). The Dissociation Between Door-to-Balloon Time Improvement and Improvements in Other Acute Myocardial Infarction Care Processes and Patient Outcomes. Arch Intern Med 169: 1411-1419 [Abstract] [Full Text]  
• Bonnefoy, E., Steg, P. G., Boutitie, F., Dubien, P.-Y., Lapostolle, F., Roncalli, J., Dissait, F., Vanzetto, G., Leizorowicz, A., Kirkorian, G., for the CAPTIM Investigators, (2009). Comparison of primary angioplasty and pre-hospital fibrinolysis in acute myocardial infarction (CAPTIM) trial: a 5-year follow-up. Eur Heart J 30: 1598-1606 [Abstract] [Full Text]  
• Huynh, T., Perron, S., O'Loughlin, J., Joseph, L., Labrecque, M., Tu, J. V., Theroux, P. (2009). Comparison of Primary Percutaneous Coronary Intervention and Fibrinolytic Therapy in ST-Segment-Elevation Myocardial Infarction: Bayesian Hierarchical Meta-Analyses of Randomized Controlled Trials and Observational Studies. Circulation 119: 3101-3109 [Abstract] [Full Text]  
• Busk, M., Kaltoft, A., Nielsen, S. S., Bottcher, M., Rehling, M., Thuesen, L., Botker, H. E., Lassen, J. F., Christiansen, E. H., Krusell, L. R., Andersen, H. R., Nielsen, T. T., Kristensen, S. D. (2009). Infarct size and myocardial salvage after primary angioplasty in patients presenting with symptoms for <12 h vs. 12-72 h. Eur Heart J 30: 1322-1330 [Abstract] [Full Text]  
• Edmond, J J, Juergens, C P, French, J K (2009). The pharmaco-invasive approach to STEMI: when should fibrinolytic-treated patients go to the "cath lab"?. Postgrad. Med. J. 85: 331-334 [Abstract] [Full Text]  
• Danchin, N., Carda, R., Chaib, A., Lepillier, A., Durand, E. (2009). Optimizing outcomes in patients with STEMI: mortality, bleeding, door-to-balloon times, and guidelines: the approach to regional systems for STEMI care: defining the ideal approach to reperfusion therapy based on recent trials. Eur Heart J Suppl 11: C25-C30 [Abstract] [Full Text]  
• Horne, S, Weston, C, Quinn, T, Hicks, A, Walker, L, Chen, R, Birkhead, J (2009). The impact of pre-hospital thrombolytic treatment on re-infarction rates: analysis of the Myocardial Infarction National Audit Project (MINAP). Heart 95: 559-563 [Abstract] [Full Text]  
• Armstrong, P. W., Westerhout, C. M., Welsh, R. C. (2009). Duration of Symptoms Is the Key Modulator of the Choice of Reperfusion for ST-Elevation Myocardial Infarction. Circulation 119: 1293-1303 [Full Text]  
• Bogaty, P. (2009). Duration of Symptoms Is Not Always the Key Modulator of the Choice of Reperfusion for ST-Elevation Myocardial Infarction. Circulation 119: 1304-1310 [Full Text]  
• Terkelsen, C J, Christiansen, E H, Sorensen, J T, Kristensen, S D, Lassen, J F, Thuesen, L, Andersen, H R, Vach, W, Nielsen, T T (2009). Primary PCI as the preferred reperfusion therapy in STEMI: it is a matter of time. Heart 95: 362-369 [Abstract] [Full Text]  
• Edmond, J J, Juergens, C P, French, J K (2009). The pharmaco-invasive approach to STEMI: when should fibrinolytic-treated patients go to the "cath lab"?. Heart 95: 358-361 [Abstract] [Full Text]  
• Blackledge, H M, Squire, I B (2009). Improving long-term outcomes following coronary artery bypass graft or percutaneous coronary revascularisation: results from a large, population-based cohort with first intervention 1995-2004. Heart 95: 304-311 [Abstract] [Full Text]  
• Hollenberg, S. M. (2009). Acute Coronary Syndromes. ACCP Crit Care Med Brd Rev 20: 129-144 [Full Text]  
• Jensen, L. O., Maeng, M., Thayssen, P., Kaltoft, A., Tilsted, H. H., Bottcher, M., Lassen, J. F., Hansen, K. N., Krusell, L. R., Rasmussen, K., Pedersen, K. E., Pedersen, L., Paaske Johnsen, S., Sorensen, H. T., Thuesen, L. (2008). Clinical Outcome After Primary Percutaneous Coronary Intervention With Drug-Eluting and Bare Metal Stents in Patients With ST-Segment Elevation Myocardial Infarction. Circ Cardiovasc Interv 1: 176-184 [Abstract] [Full Text]  
• Danchin, N., Durand, E., Blanchard, D. (2008). Pre-hospital thrombolysis in perspective. Eur Heart J 29: 2835-2842 [Abstract] [Full Text]  
• Vlaar, P. J., Svilaas, T., Damman, K., de Smet, B. J.G.L., Tijssen, J. G.P., Hillege, H. L., Zijlstra, F. (2008). Impact of Pretreatment With Clopidogrel on Initial Patency and Outcome in Patients Treated With Primary Percutaneous Coronary Intervention for ST-Segment Elevation Myocardial Infarction: A Systematic Review. Circulation 118: 1828-1836 [Abstract] [Full Text]  
• Antman, E. M. (2008). Time Is Muscle: Translation Into Practice. J Am Coll Cardiol 52: 1216-1221 [Abstract] [Full Text]  
• Flesch, M., Hagemeister, J., Berger, H.-J., Schiefer, A., Schynkowski, S., Klein, M., Sahebdjami, S., vom Dahl, S., Fehske, W., Mies, R., von Eiff, M., Pfaff, H., Frommolt, P., Hoepp, H.-W. (2008). Implementation of Guidelines for the Treatment of Acute ST-Elevation Myocardial Infarction: The Cologne Infarction Model Registry. Circ Cardiovasc Interv 1: 95-102 [Abstract] [Full Text]  
• Nallamothu, B. K., Hayward, R. A., Bates, E. R. (2008). Beyond the Randomized Clinical Trial: The Role of Effectiveness Studies in Evaluating Cardiovascular Therapies. Circulation 118: 1294-1303 [Full Text]  
• Terkelsen, C. J., Nielsen, T. T. (2008). Reperfusion Strategies in Acute ST-Segment Elevation Myocardial Infarction: Acute Angioplasty May Be Feasible for the Majority of U.S. Citizens. J Am Coll Cardiol 52: 966-967 [Full Text]  
• Kelbaek, H., Thuesen, L., Helqvist, S., Clemmensen, P., Klovgaard, L., Kaltoft, A., Andersen, B., Thuesen, H., Engstrom, T., Botker, H. E., Saunamaki, K., Krusell, L. R., Jorgensen, E., Hansen, H.-H. T., Christiansen, E. H., Ravkilde, J., Kober, L., Kofoed, K. F., Terkelsen, C. J., Lassen, J. F., for the DEDICATION Investigators, (2008). Drug-Eluting Versus Bare Metal Stents in Patients With ST-Segment-Elevation Myocardial Infarction: Eight-Month Follow-Up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) Trial. Circulation 118: 1155-1162 [Abstract] [Full Text]  
• Manari, A., Ortolani, P., Guastaroba, P., Casella, G., Vignali, L., Varani, E., Piovaccari, G., Guiducci, V., Percoco, G., Tondi, S., Passerini, F., Santarelli, A., Marzocchi, A. (2008). Clinical impact of an inter-hospital transfer strategy in patients with ST-elevation myocardial infarction undergoing primary angioplasty: the Emilia-Romagna ST-segment elevation acute myocardial infarction network. Eur Heart J 29: 1834-1842 [Abstract] [Full Text]  
• Chakrabarti, A., Krumholz, H. M., Wang, Y., Rumsfeld, J. S., Nallamothu, B. K., for the National Cardiovascular Data Registry, (2008). Time-to-reperfusion in patients undergoing interhospital transfer for primary percutaneous coronary intervention in the U.S: an analysis of 2005 and 2006 data from the National Cardiovascular Data Registry.. J Am Coll Cardiol 51: 2442-2443 [Full Text]  
• Ellis, S. G., Tendera, M., de Belder, M. A., van Boven, A. J., Widimsky, P., Janssens, L., Andersen, H.R., Betriu, A., Savonitto, S., Adamus, J., Peruga, J. Z., Kosmider, M., Katz, O., Neunteufl, T., Jorgova, J., Dorobantu, M., Grinfeld, L., Armstrong, P., Brodie, B. R., Herrmann, H. C., Montalescot, G., Neumann, F.-J., Effron, M. B., Barnathan, E. S., Topol, E. J., the FINESSE Investigators, (2008). Facilitated PCI in Patients with ST-Elevation Myocardial Infarction. NEJM 358: 2205-2217 [Abstract] [Full Text]  
• Busk, M., Maeng, M., Rasmussen, K., Kelbaek, H., Thayssen, P., Abildgaard, U., Vigholt, E., Mortensen, L. S., Thuesen, L., Kristensen, S. D., Nielsen, T. T., Andersen, H. R., for the DANAMI-2 Investigators, (2008). The Danish multicentre randomized study of fibrinolytic therapy vs. primary angioplasty in acute myocardial infarction (the DANAMI-2 trial): outcome after 3 years follow-up. Eur Heart J 29: 1259-1266 [Abstract] [Full Text]  
• Holmvang, L., Mickley, H. (2008). Review: Gender differences following percutaneous coronary intervention. Ther Adv Cardiovasc Dis 2: 109-113 [Abstract]  
• Kelbaek, H., Terkelsen, C. J., Helqvist, S., Lassen, J. F., Clemmensen, P., Klovgaard, L., Kaltoft, A., Engstrom, T., Botker, H. E., Saunamaki, K., Krusell, L. R., Jorgensen, E., Hansen, H.-H. T., Christiansen, E. H., Ravkilde, J., Kober, L., Kofoed, K. F., Thuesen, L. (2008). Randomized comparison of distal protection versus conventional treatment in primary percutaneous coronary intervention: the drug elution and distal protection in ST-elevation myocardial infarction (DEDICATION) trial.. J Am Coll Cardiol 51: 899-905 [Abstract] [Full Text]  
• Aguirre, F. V., Varghese, J. J., Kelley, M. P., Lam, W., Lucore, C. L., Gill, J. B., Page, L., Turner, L., Davis, C., Mikell, F. L. (2008). Rural Interhospital Transfer of ST-Elevation Myocardial Infarction Patients for Percutaneous Coronary Revascularization: The Stat Heart Program. Circulation 117: 1145-1152 [Abstract] [Full Text]  
• Jollis, J. G. (2008). Tardy pardee: moving medical effectiveness to the forefront.. J Am Coll Cardiol Intv 1: 105-107 [Full Text]  
• Ratcliffe, A T, Pepper, C (2008). Thrombolysis or primary angioplasty? Reperfusion therapy for myocardial infarction in the UK. Postgrad. Med. J. 84: 73-77 [Abstract] [Full Text]  
• Le May, M. R., So, D. Y., Dionne, R., Glover, C. A., Froeschl, M. P.V., Wells, G. A., Davies, R. F., Sherrard, H. L., Maloney, J., Marquis, J.-F., O'Brien, E. R., Trickett, J., Poirier, P., Ryan, S. C., Ha, A., Joseph, P. G., Labinaz, M. (2008). A Citywide Protocol for Primary PCI in ST-Segment Elevation Myocardial Infarction. NEJM 358: 231-240 [Abstract] [Full Text]  
• Wilson, J. M., Willerson, J. T. (2008). Myocardial Revascularization with Percutaneous Devices. Card Surg Adult 3: 573-598 [Full Text]  
• Eskola, M. J., Holmvang, L., Nikus, K. C., Sclarovsky, S., Tilsted, H.-H., Huhtala, H., Niemela, K. O., Clemmensen, P. (2007). The electrocardiographic window of opportunity to treat vs. the different evolving stages of ST-elevation myocardial infarction: correlation with therapeutic approach, coronary anatomy, and outcome in the DANAMI-2 trial. Eur Heart J 28: 2985-2991 [Abstract] [Full Text]  
• Kasapis, C., Nallamothu, B. K. (2007). Use of the electrocardiogram in optimizing reperfusion for ST-elevation myocardial infarction: a new role for an old tool?. Eur Heart J 28: 2957-2959 [Full Text]  
• Mudespacher, D., Radovanovic, D., Camenzind, E., Essig, M., Bertel, O., Erne, P., Eberli, F. R., Gutzwiller, F. (2007). Admission glycaemia and outcome in patients with acute coronary syndrome. Diabetes and Vascular Disease Research 4: 346-352 [Abstract]  
• Tjandrawidjaja, M. C., Fu, Y., Al-Khalidi, H., Todaro, T. G., Adams, P., Van de Werf, F., Granger, C. B., Armstrong, P. W., on behalf of the APEX-AMI Investigators, (2007). Failure of investigator adherence to electrocardiographic entry criteria is frequent and influences clinical outcomes: lessons from APEX-AMI. Eur Heart J 28: 2850-2857 [Abstract] [Full Text]  
• Carstensen, S., Nelson, G. C.I., Hansen, P. S., Macken, L., Irons, S., Flynn, M., Kovoor, P., Soo Hoo, S. Y., Ward, M. R., Rasmussen, H. H. (2007). Field triage to primary angioplasty combined with emergency department bypass reduces treatment delays and is associated with improved outcome. Eur Heart J 28: 2313-2319 [Abstract] [Full Text]  
• Brophy, J. M (2007). Has thrombolysis lost its mojo?. Heart 93: 1167-1169 [Full Text]  
• Asseburg, C., Bravo Vergel, Y., Palmer, S., Fenwick, E., de Belder, M., Abrams, K. R, Sculpher, M. (2007). Assessing the effectiveness of primary angioplasty compared with thrombolysis and its relationship to time delay: a Bayesian evidence synthesis. Heart 93: 1244-1250 [Abstract] [Full Text]  
• Henry, T. D., Sharkey, S. W., Burke, M. N., Chavez, I. J., Graham, K. J., Henry, C. R., Lips, D. L., Madison, J. D., Menssen, K. M., Mooney, M. R., Newell, M. C., Pedersen, W. R., Poulose, A. K., Traverse, J. H., Unger, B. T., Wang, Y. L., Larson, D. M. (2007). A Regional System to Provide Timely Access to Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction. Circulation 116: 721-728 [Abstract] [Full Text]  
• Ting, H. H., Rihal, C. S., Gersh, B. J., Haro, L. H., Bjerke, C. M., Lennon, R. J., Lim, C.-C., Bresnahan, J. F., Jaffe, A. S., Holmes, D. R., Bell, M. R. (2007). Regional Systems of Care to Optimize Timeliness of Reperfusion Therapy for ST-Elevation Myocardial Infarction: The Mayo Clinic STEMI Protocol. Circulation 116: 729-736 [Abstract] [Full Text]  
• Jolobe, O. M. (2007). Long-term outcomes of patients with acute myocardial infarction. Eur Heart J 28: 1911-1911 [Full Text]  
• Faxon, D. P. (2007). Development of Systems of Care for ST-Elevation Myocardial Infarction Patients: Current State of ST-Elevation Myocardial Infarction Care. Circulation 116: e29-e32 [Full Text]  
• Moyer, P., Ornato, J. P., Brady, W. J. Jr, Davis, L. L., Ghaemmaghami, C. A., Gibler, W. B., Mears, G., Mosesso, V. N. Jr, Zane, R. D. (2007). Development of Systems of Care for ST-Elevation Myocardial Infarction Patients: The Emergency Medical Services and Emergency Department Perspective. Circulation 116: e43-e48 [Full Text]  
• Ellrodt, G., Sadwin, L. B., Aversano, T., Brodie, B., O'Brien, P. K., Gray, R., Hiratzka, L. F., Larson, D. (2007). Development of Systems of Care for ST-Elevation Myocardial Infarction Patients: The Non-Percutaneous Coronary Intervention-Capable (ST-Elevation Myocardial Infarction Referral) Hospital Perspective. Circulation 116: e49-e54 [Full Text]  
• Granger, C. B., Henry, T. D., Bates, W. E. R., Cercek, B., Weaver, W. D., Williams, D. O. (2007). Development of Systems of Care for ST-Elevation Myocardial Infarction Patients: The Primary Percutaneous Coronary Intervention (ST-Elevation Myocardial Infarction Receiving) Hospital Perspective. Circulation 116: e55-e59 [Full Text]  
• Nallamothu, B. K., Krumholz, H. M., Ko, D. T., LaBresh, K. A., Rathore, S., Roe, M. T., Schwamm, L. (2007). Development of Systems of Care for ST-Elevation Myocardial Infarction Patients: Gaps, Barriers, and Implications. Circulation 116: e68-e72 [Full Text]  
• Timmer, J. R., Ottervanger, J. P., de Boer, M.-J., Boersma, E., Grines, C. L., Westerhout, C. M., Simes, R. J., Granger, C. B., Zijlstra, F., for the Primary Coronary Angioplasty vs Thrombolys, (2007). Primary Percutaneous Coronary Intervention Compared With Fibrinolysis for Myocardial Infarction in Diabetes Mellitus: Results From the Primary Coronary Angioplasty vs Thrombolysis-2 Trial. Arch Intern Med 167: 1353-1359 [Abstract] [Full Text]  
• Kiernan, T. J., Ting, H. H., Gersh, B. J. (2007). Facilitated percutaneous coronary intervention: current concepts, promises, and pitfalls. Eur Heart J 28: 1545-1553 [Abstract] [Full Text]  
• de Villiers, J. S., Anderson, T., McMeekin, J. D., Leung, R. C.M., Traboulsi, M., for the Foothills Interventional Cardiology Servic, (2007). Expedited transfer for primary percutaneous coronary intervention: a program evaluation. CMAJ 176: 1833-1838 [Abstract] [Full Text]  
• Alexander, K. P., Newby, L. K., Armstrong, P. W., Cannon, C. P., Gibler, W. B., Rich, M. W., Van de Werf, F., White, H. D., Weaver, W. D., Naylor, M. D., Gore, J. M., Krumholz, H. M., Ohman, E. M. (2007). Acute Coronary Care in the Elderly, Part II: ST-Segment-Elevation Myocardial Infarction: A Scientific Statement for Healthcare Professionals From the American Heart Association Council on Clinical Cardiology: In Collaboration With the Society of Geriatric Cardiology. Circulation 115: 2570-2589 [Abstract] [Full Text]  
• Dalby, M., Roughton, M., Ilsley, C., de LaCoussaye, J. E., Carli, P. A., Umans, V. A., Peels, H. O., Wharton, T., Hall, J., Roberts, T., deBelder, M., Townend, J. N., Bradley, E. H., Krumholz, H. M., Moscucci, M., Eagle, K. A. (2007). Door-to-Balloon Time in Acute Myocardial Infarction. NEJM 356: 1475-1479 [Full Text]  
• Rihal, C. S., Jaffe, A. S., Holmes, D. R. Jr, Ting, H. H., Gersh, B. J., Bell, M. R. (2007). Percutaneous Coronary Intervention vs Thrombolysis for ST-Elevation Myocardial Infarction. JAMA 297: 1313-1313 [Full Text]  
• Widimsky, P., Bilkova, D., Penicka, M., Novak, M., Lanikova, M., Porizka, V., Groch, L., Zelizko, M., Budesinsky, T., Aschermann, M., on behalf of the PRAGUE Study Group Investigators, (2007). Long-term outcomes of patients with acute myocardial infarction presenting to hospitals without catheterization laboratory and randomized to immediate thrombolysis or interhospital transport for primary percutaneous coronary intervention. Five years' follow-up of the PRAGUE-2 trial. Eur Heart J 28: 679-684 [Abstract] [Full Text]  
• Hollenbeak, C. S., Fitzgibbons, J. P., Rossi, M., Morris, D. L., Stillman, P. (2007). The Impact of Percutaneous Coronary Interventions on Outcomes for Acute Myocardial Infarction in Pennsylvania. American Journal of Medical Quality 22: 85-94 [Abstract]  
• Hofsten, D. E., Wachtell, K., Lund, B., Molgaard, H., Egstrup, K., on behalf of the DANAMI-2 Investigators, (2007). Prevalence and prognostic implications of non-sustained ventricular tachycardia in ST-segment elevation myocardial infarction after revascularization with either fibrinolysis or primary angioplasty. Eur Heart J 28: 407-414 [Abstract] [Full Text]  
• Buch, P, Rasmussen, S, Gislason, G H, Rasmussen, J N, Kober, L, Gadsboll, N, Stender, S, Madsen, M, Torp-Pedersen, C, Abildstrom, S Z (2007). Temporal decline in the prognostic impact of a recurrent acute myocardial infarction 1985 to 2002. Heart 93: 210-215 [Abstract] [Full Text]  
• Steg, P. G., Lopez-Sendon, J., Lopez de Sa, E., Goodman, S. G., Gore, J. M., Anderson, F. A. Jr, Himbert, D., Allegrone, J., Van de Werf, F., for the GRACE Investigators, (2007). External Validity of Clinical Trials in Acute Myocardial Infarction. Arch Intern Med 167: 68-73 [Abstract] [Full Text]  
• Van de Werf, F. J. (2006). Fine-Tuning the Selection of a Reperfusion Strategy. Circulation 114: 2002-2003 [Full Text]  
• Van Brabandt, H., Camberlin, C., Vrijens, F., Parmentier, Y., Ramaekers, D., Bonneux, L. (2006). More is not better in the early care of acute myocardial infarction: a prospective cohort analysis on administrative databases. Eur Heart J 27: 2649-2654 [Abstract] [Full Text]  
• Sejersten, M, Birnbaum, Y, Ripa, R S, Maynard, C, Wagner, G S, Clemmensen, P, for the DANAMI-2 Investigators, (2006). Influences of electrocardiographic ischaemia grades and symptom duration on outcomes in patients with acute myocardial infarction treated with thrombolysis versus primary percutaneous coronary intervention: results from the DANAMI-2 trial. Heart 92: 1577-1582 [Abstract] [Full Text]  
• Ting, H. H., Yang, E. H., Rihal, C. S. (2006). Narrative review: reperfusion strategies for ST-segment elevation myocardial infarction.. ANN INTERN MED 145: 610-617 [Abstract] [Full Text]  
• Stenestrand, U., Lindback, J., Wallentin, L., for the RIKS-HIA Registry, (2006). Long-term outcome of primary percutaneous coronary intervention vs prehospital and in-hospital thrombolysis for patients with ST-elevation myocardial infarction.. JAMA 296: 1749-1756 [Abstract] [Full Text]  
• Borden, W. B., Faxon, D. P. (2006). Facilitated Percutaneous Coronary Intervention. J Am Coll Cardiol 48: 1120-1128 [Abstract] [Full Text]  
• Kaltoft, A., Bottcher, M., Nielsen, S. S., Hansen, H.-H. T., Terkelsen, C., Maeng, M., Kristensen, J., Thuesen, L., Krusell, L. R., Kristensen, S. D., Andersen, H. R., Lassen, J. F., Rasmussen, K., Rehling, M., Nielsen, T. T., Botker, H. E. (2006). Routine Thrombectomy in Percutaneous Coronary Intervention for Acute ST-Segment-Elevation Myocardial Infarction: A Randomized, Controlled Trial. Circulation 114: 40-47 [Abstract] [Full Text]  
• Kovacs, I. B., Yamamoto, J. (2006). Spontaneous Thrombolysis: A Forgotten Determinant of Life or Death. CLIN APPL THROMB HEMOST 12: 358-363 [Abstract]  
• Armstrong, P. W., WEST Steering Committee, (2006). A comparison of pharmacologic therapy with/without timely coronary intervention vs. primary percutaneous intervention early after ST-elevation myocardial infarction: the WEST (Which Early ST-elevation myocardial infarction Therapy) study. Eur Heart J 27: 1530-1538 [Abstract] [Full Text]  
• Steg, P. G., Danchin, N. (2006). WEST: new data on the integration of early thrombolysis and mechanical intervention in the early management of STEMI. Eur Heart J 27: 1511-1512 [Full Text]  
• Kalla, K., Christ, G., Karnik, R., Malzer, R., Norman, G., Prachar, H., Schreiber, W., Unger, G., Glogar, H. D., Kaff, A., Laggner, A. N., Maurer, G., Mlczoch, J., Slany, J., Weber, H. S., Huber, K., for the Vienna STEMI Registry Group, (2006). Implementation of Guidelines Improves the Standard of Care: The Viennese Registry on Reperfusion Strategies in ST-Elevation Myocardial Infarction (Vienna STEMI Registry). Circulation 113: 2398-2405 [Abstract] [Full Text]  
• Armstrong, P. W., Chang, W.-C., Wallentin, L., Goldstein, P., Granger, C. B., Bogaerts, K., Danays, T., Van de Werf, F., for the ASSENT-3 and ASSENT-3 PLUS Investigators, (2006). Efficacy and safety of unfractionated heparin versus enoxaparin: a pooled analysis of ASSENT-3 and -3 PLUS data.. CMAJ 174: 1421-1426 [Abstract] [Full Text]  
• The American Heart Association's Acute Myocardial, , Jacobs, A. K., Antman, E. M., Ellrodt, G., Faxon, D. P., Gregory, T., Mensah, G. A., Moyer, P., Ornato, J., Peterson, E. D., Sadwin, L., Smith, S. C. (2006). Recommendation to Develop Strategies to Increase the Number of ST-Segment-Elevation Myocardial Infarction Patients With Timely Access to Primary Percutaneous Coronary Intervention. Circulation 113: 2152-2163 [Abstract] [Full Text]  
• Rathore, S. S., Epstein, A. J., Nallamothu, B. K., Krumholz, H. M. (2006). Regionalization of ST-Segment Elevation Acute Coronary Syndromes Care: Putting a National Policy in Proper Perspective. J Am Coll Cardiol 47: 1346-1349 [Abstract] [Full Text]  
• Henry, T. D., Atkins, J. M., Cunningham, M. S., Francis, G. S., Groh, W. J., Hong, R. A., Kern, K. B., Larson, D. M., Ohman, E. M., Ornato, J. P., Peberdy, M. A., Rosenberg, M. J., Weaver, W. D. (2006). ST-Segment Elevation Myocardial Infarction: Recommendations on Triage of Patients to Heart Attack Centers: Is it Time for a National Policy for the Treatment of ST-Segment Elevation Myocardial Infarction?. J Am Coll Cardiol 47: 1339-1345 [Abstract] [Full Text]  
• Boersma, E., The Primary Coronary Angioplasty vs. Thrombolysis, (2006). Does time matter? A pooled analysis of randomized clinical trials comparing primary percutaneous coronary intervention and in-hospital fibrinolysis in acute myocardial infarction patients. Eur Heart J 27: 779-788 [Abstract] [Full Text]  
• (2006). Additional Information. JAMA 295: E1-E6 [Full Text]  
• Serruys, P. W., Kutryk, M. J.B., Ong, A. T.L. (2006). Coronary-Artery Stents. NEJM 354: 483-495 [Full Text]  
• Terkelsen, C. J., Norgaard, B. L., Lassen, J. F., Poulsen, S. H., Gerdes, J. C., Sloth, E., Gotzsche, L. B.-H., Romer, F. K., Thuesen, L., Nielsen, T. T., Andersen, H. R. (2006). Potential significance of spontaneous and interventional ST-changes in patients transferred for primary percutaneous coronary intervention: observations from the ST-MONitoring in Acute Myocardial Infarction study (The MONAMI study). Eur Heart J 27: 267-275 [Abstract] [Full Text]