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Previous Volume 349:760-766 August 21, 2003 Number 8 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Supplementary Material Perspective by Kaiser, U. B. Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

The ovarian hyperstimulation syndrome most often occurs as an iatrogenic complication of ovarian-stimulation treatments for in vitro fertilization (the incidence of severe forms ranges from 0.5 to 5 percent).¹ The clinical manifestations vary from abdominal distention and discomfort to potentially life-threatening, massive ovarian enlargement and capillary leak with fluid sequestration in a third space.² Although the presence of human chorionic gonadotropin is invariably associated with the condition, the pathophysiological mechanism remains undefined.³

The overproduction of endogenous chorionic gonadotropin during pregnancy has been associated with spontaneous ovarian hyperstimulation syndrome (also termed hyperreactio luteinalis of the first trimester), as well as with . . . [Full Text of this Article]

Case Report

Methods

Sequencing of the Gene for the Follicle-Stimulating Hormone Receptor

Functional Characterization of the Mutation

Results

Sequence Determination

Functional Characterization of the Mutant Receptor

Discussion

Source Information

From the Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM), Faculté de Médecine, Université Libre de Bruxelles (G.S., G.V., S.C.); and the Service de Génétique Médicale (G.S., G.V.) and Clinique de Fertilité (A.D.), Hôpital Erasme — both in Brussels, Belgium; and the Department of Obstetrics, Gynecology, and Reproductive Sciences (O.O., R.P.) and the Reproductive Biology Research Unit (R.P.), College of Medicine, University of Saskatchewan, Saskatoon, Canada.

Address reprint requests to Dr. Vassart at the IRIBHM, 808 Rte. de Lennik, B-1070 Brussels, Belgium, or at gvassart@ulb.ac.be.

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