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Volume 349:813 August 21, 2003 Number 8
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Folate Supplementation in Sickle Cell Anemia

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by Dhar, M.
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To the Editor: The case report by Dhar et al. (May 29 issue)1 serves as a useful reminder that patients for whom high-dose folic acid is prescribed should have their vitamin B12 status checked periodically. However, the report errs in two ways.

First, it recommends that routine folate supplementation be discontinued in patients with sickle cell disease because of its unproven clinical benefit. Instead, what needs to be proved is that the lack of supplementation is innocuous. Dietary folate intake is often borderline, and intake is commonly further diminished in persons with chronic diseases. The folate requirement in patients with . . . [Full Text of this Article]



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