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Volume 349:908-909 August 28, 2003 Number 9
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Risk Stratification in the Long-QT Syndrome

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by Priori, S. G.
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To the Editor: Priori et al. (May 8 issue)1 describe a new risk-stratification algorithm for the long-QT syndrome, one based on genotype. As the authors note, the natural history of the long-QT syndrome varies not only among families with mutations that map to different loci, but also among families with mutations in the same gene. The management algorithm they describe, however, does not fully account for these types of variation.

To interpret the data presented, readers need to know the structure of the study population, whether the events seen were clustered within families, and the effect of restricting the analysis . . . [Full Text of this Article]



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