To the Editor: Although secondary cancer is a well-establishedlong-term complication of hematopoietic stem-cell transplantation,1the transmission of hematologic cancers through marrow or solid-organtransplantation is exceptional.2 Moreover, to our knowledge,it has not been reported after peripheral-blood stem-cell transplantation.
A nine-year-old African child received a diagnosis of sicklecell disease (hemoglobin SC) in 1991. Between 1991 and 2001,he had multiple vaso-occlusive crises, despite hydroxyurea therapy.He was referred to us at the age of 19 years for transplantationof peripheral-blood stem-cells from an HLA-identical brotherwho was heterozygous for sickle cell disease.3,4 Before peripheral-bloodstem-cell mobilization with a . . . [Full Text of this Article]
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