FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Previous Volume 350:21-28 January 1, 2004 Number 1 Next

	Full Text PDF PDA Full Text PowerPoint Slide Set Perspective by MacGillivray, T. E. Letters Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear PubMed Citation

ABSTRACT

Background The effect of the use of coronary-artery bypass surgery without cardiopulmonary bypass and cardiac arrest ("off pump") on graft patency remains uncertain. We undertook a prospective, randomized, controlled study to compare graft-patency rates and clinical outcomes in off-pump surgery with conventional, "on-pump" surgery.

Methods We randomly assigned 50 patients to undergo on-pump coronary-artery bypass grafting and 54 to undergo off-pump surgery. Surgical and anesthetic techniques were standardized for both groups. Clinical outcomes and troponin T levels were measured. Three months later, the patients underwent coronary angiography, including quantitative analysis.

Results The mean age of the patients was 63 years, and 87 percent were men. The on-pump group received a mean of 3.4 grafts, and the off-pump group 3.1 (P=0.41). There were no deaths. There was no significant difference in the median postoperative length of stay between the two groups (seven days in each group). The area under the curve of troponin T levels was higher during the first 72 hours in the on-pump group than in the off-pump group (30.96 hr • µg per liter vs. 19.33 hr • µg per liter, P=0.02). At three months, 127 of 130 grafts were patent in the on-pump group (98 percent), as compared with 114 of 130 in the off-pump group (88 percent, P=0.002). The patency rate was higher for all graft territories in the on-pump group than in the off-pump group.

Conclusions In this randomized study, off-pump coronary surgery was as safe as on-pump surgery and caused less myocardial damage. However, the graft-patency rate was lower at three months in the off-pump group than in the on-pump group, and this difference has implications with respect to the long-term outcome.

Source Information

From the Royal Brompton and Harefield National Health Service Trust (N.E.K., A.D.S., R.M., M.F., J.C., S.D.); the Imperial College of Science, Technology, and Medicine, National Heart and Lung Institute (P.C., J.P.); and the London School of Hygiene and Tropical Hygiene (D.W.) — all in London; and the Center and Division of Cardiology, University Hospital, Geneva (U.S.).

Address reprint requests to Dr. Khan at the Clinical Trials and Evaluation Unit, Royal Brompton Hospital, London SW3 6NP, United Kingdom, or at r.mister{at}rbh.nthames.nhs.uk.

Full Text of this Article

Related Letters:

Off-Pump versus On-Pump Coronary Bypass Surgery
deGuzman B. J., Subramaniam M. H., Dewey T. M., Magee M. J., Mack M. J., Desai N. D., Fremes S. E., Svedjeholm R., Dahlin L.-G., Khan N. E., DeSouza A. C., Pepper J. R.
Extract | Full Text | PDF  
N Engl J Med 2004; 350:1791-1793, Apr 22, 2004. Correspondence

This article has been cited by other articles:

• Shroyer, A. L., Grover, F. L., Hattler, B., Collins, J. F., McDonald, G. O., Kozora, E., Lucke, J. C., Baltz, J. H., Novitzky, D., the Veterans Affairs Randomized On/Off Bypass (ROO, (2009). On-Pump versus Off-Pump Coronary-Artery Bypass Surgery. NEJM 361: 1827-1837 [Abstract] [Full Text]  
• Sezai, A., Hata, M., Niino, T., Yoshitake, I., Unosawa, S., Wakui, S., Osaka, S., Takayama, T., Kasamaki, Y., Hirayama, A., Minami, K. (2009). Influence of continuous infusion of low-dose human atrial natriuretic peptide on renal function during cardiac surgery: a randomized controlled study.. J Am Coll Cardiol 54: 1058-1064 [Abstract] [Full Text]  
• Takagi, H., Umemoto, T. (2009). Graft patency in coronary artery bypass versus off-pump coronary artery bypass. J. Thorac. Cardiovasc. Surg. 138: 792-793 [Full Text]  
• Abu-Omar, Y., Taggart, D. P. (2009). The present status of off-pump coronary artery bypass grafting. Eur. J. Cardiothorac. Surg. 36: 312-321 [Abstract] [Full Text]  
• Tanaka, E., Chen, F. Y., Flaumenhaft, R., Graham, G. J., Laurence, R. G., Frangioni, J. V. (2009). Real-time assessment of cardiac perfusion, coronary angiography, and acute intravascular thrombi using dual-channel near-infrared fluorescence imaging. J. Thorac. Cardiovasc. Surg. 138: 133-140 [Abstract] [Full Text]  
• Chu, D., Bakaeen, F. G., Dao, T. K., LeMaire, S. A., Coselli, J. S., Huh, J. (2009). On-Pump Versus Off-Pump Coronary Artery Bypass Grafting in a Cohort of 63,000 Patients.. Ann. Thorac. Surg. 87: 1820-1827 [Abstract] [Full Text]  
• Waseda, K., Ako, J., Hasegawa, T., Shimada, Y., Ikeno, F., Ishikawa, T., Demura, Y., Hatada, K., Yock, P. G., Honda, Y., Fitzgerald, P. J., Takahashi, M. (2009). Intraoperative fluorescence imaging system for on-site assessment of off-pump coronary artery bypass graft.. J Am Coll Cardiol Img 2: 604-612 [Abstract] [Full Text]  
• Ward, H. B., Kelly, R. F., Weir, E. K. (2009). Assessment of graft patency during coronary artery bypass graft surgery mitigating the risk.. J Am Coll Cardiol Img 2: 613-615 [Full Text]  
• Konety, S. H., Rosenthal, G. E., Vaughan-Sarrazin, M. S. (2009). Surgical volume and outcomes of off-pump coronary artery bypass graft surgery: Does it matter?. J. Thorac. Cardiovasc. Surg. 137: 1116-23.e1 [Abstract] [Full Text]  
• Buxton, B. F., Hayward, P. A.R., Newcomb, A. E., Moten, S., Seevanayagam, S., Gordon, I. (2009). Choice of conduits for coronary artery bypass grafting: craft or science?. Eur. J. Cardiothorac. Surg. 35: 658-670 [Abstract] [Full Text]  
• Fu, S.-p., Zheng, Z., Yuan, X., Zhang, S.-j., Gao, H.-w., Li, Y., Hu, S.-s. (2009). Impact of Off-Pump Techniques on Sex Differences in Early and Late Outcomes After Isolated Coronary Artery Bypass Grafts. Ann. Thorac. Surg. 87: 1090-1096 [Abstract] [Full Text]  
• Magee, M. J., Hebert, E., Herbert, M. A., Prince, S. L., Dewey, T. M., Culica, D. V., Mack, M. J. (2009). Fewer Grafts Performed in Off-Pump Bypass Surgery: Patient Selection or Incomplete Revascularization?. Ann. Thorac. Surg. 87: 1113-1118 [Abstract] [Full Text]  
• Puehler, T., Haneya, A., Philipp, A., Wiebe, K., Keyser, A., Rupprecht, L., Hirt, S., Kobuch, R., Diez, C., Hilker, M., Schmid, C. (2009). Minimal extracorporeal circulation: an alternative for on-pump and off-pump coronary revascularization.. Ann. Thorac. Surg. 87: 766-772 [Abstract] [Full Text]  
• Fattouch, K., Guccione, F., Dioguardi, P., Sampognaro, R., Corrado, E., Caruso, M., Ruvolo, G. (2009). Off-pump versus on-pump myocardial revascularization in patients with ST-segment elevation myocardial infarction: a randomized trial.. J. Thorac. Cardiovasc. Surg. 137: 650-656 [Abstract] [Full Text]  
• Angelini, G. D., Culliford, L., Smith, D. K., Hamilton, M. C.K., Murphy, G. J., Ascione, R., Baumbach, A., Reeves, B. C. (2009). Effects of on- and off-pump coronary artery surgery on graft patency, survival, and health-related quality of life: long-term follow-up of 2 randomized controlled trials.. J. Thorac. Cardiovasc. Surg. 137: 295-303 [Abstract] [Full Text]  
• Chandrasena, L. G., Peiris, H., Waikar, H. D. (2009). Biochemical Changes Associated with Reperfusion After Off-Pump and On-Pump Coronary Artery Bypass Graft Surgery. Annals of Clinical & Laboratory Science 39: 372-377 [Abstract] [Full Text]  
• Crea, F., Camici, P. G., De Caterina, R., Lanza, G. A. (2009). CHAPTER 17 Chronic Ischaemic Heart Disease. ESC Textbook of Cardiovascular Medicine 2: med-9780199566990-chapter-med-9780199566990-chapter [Abstract] [Full Text]  
• Moller, C. H., Penninga, L., Wetterslev, J., Steinbruchel, D. A., Gluud, C. (2008). Clinical outcomes in randomized trials of off- vs. on-pump coronary artery bypass surgery: systematic review with meta-analyses and trial sequential analyses. Eur Heart J 29: 2601-2616 [Abstract] [Full Text]  
• Li, Y., Zheng, Z., Hu, S. (2008). Early and long-term outcomes in the elderly: Comparison between off-pump and on-pump techniques in 1191 patients undergoing coronary artery bypass grafting. J. Thorac. Cardiovasc. Surg. 136: 657-664 [Abstract] [Full Text]  
• Sistino, J. (2008). Using decision-analysis and meta-analysis to predict coronary artery bypass surgical outcomes - a model for comparing off-pump surgery to miniaturized cardiopulmonary bypass circuits. Perfusion 23: 255-260 [Abstract]  
• Suwalski, G., Suwalski, P., Filipiak, K. J., Postula, M., Majstrak, F., Opolski, G. (2008). The effect of off-pump coronary artery bypass grafting on platelet activation in patients on aspirin therapy until surgery day.. Eur. J. Cardiothorac. Surg. 34: 365-369 [Abstract] [Full Text]  
• Collins, P., Webb, C. M., Chong, C. F., Moat, N. E., for the Radial Artery Versus Saphenous Vein Patenc, (2008). Radial Artery Versus Saphenous Vein Patency Randomized Trial: Five-Year Angiographic Follow-Up. Circulation 117: 2859-2864 [Abstract] [Full Text]  
• Englberger, L., Streich, M., Tevaearai, H., Carrel, T. P. (2008). Different anticoagulation strategies in off-pump coronary artery bypass operations: a European survey. ICVTS 7: 378-382 [Abstract] [Full Text]  
• Briffa, N. (2008). Off pump coronary artery bypass: a passing fad or ready for prime time?. Eur Heart J 29: 1346-1349 [Abstract] [Full Text]  
• Svennevig, K, Hoel, T., Thiara, A., Kolset, S., Castelheim, A, Mollnes, T., Brosstad, F, Fosse, E, Svennevig, J. (2008). Syndecan-1 plasma levels during coronary artery bypass surgery with and without cardiopulmonary bypass. Perfusion 23: 165-171 [Abstract]  
• Suyker, W. J.L., Borst, C. (2008). Coronary Connector Devices: Analysis of 1,469 Anastomoses in 1,216 Patients. Ann. Thorac. Surg. 85: 1828-1836 [Abstract] [Full Text]  
• Davidson, M. J. (2008). Can the Off-Pump Coronary Artery Bypass Debate Shed Light on Postoperative Right Heart Dysfunction?. Circulation 117: 2181-2183 [Full Text]  
• Raja, S. G, Dreyfus, G. D (2008). Current Status of Off-pump Coronary Artery Bypass Surgery. Asian Cardiovasc. Thorac. Ann. 16: 164-178 [Abstract] [Full Text]  
• Miyahara, K., Matsuura, A., Takemura, H., Saito, S., Sawaki, S., Yoshioka, T., Ito, H. (2008). On-pump beating-heart coronary artery bypass grafting after acute myocardial infarction has lower mortality and morbidity. J. Thorac. Cardiovasc. Surg. 135: 521-526 [Abstract] [Full Text]  
• Balacumaraswami, L., Abu-Omar, Y., Selvanayagam, J., Pigott, D., Taggart, D. P. (2008). The effects of on-pump and off-pump coronary artery bypass grafting on intraoperative graft flow in arterial and venous conduits defined by a flow/pressure ratio. J. Thorac. Cardiovasc. Surg. 135: 533-539 [Abstract] [Full Text]  
• Masoumi, M., Saidi, M. R, Rostami, F., Sepahi, H., Roushani, D. (2008). Off-Pump Coronary Artery Bypass Grafting in Left Ventricular Dysfunction. Asian Cardiovasc. Thorac. Ann. 16: 16-20 [Abstract] [Full Text]  
• Kim, K.-B., Cho, K. R., Jeong, D. S. (2008). Midterm angiographic follow-up after off-pump coronary artery bypass: serial comparison using early, 1-year, and 5-year postoperative angiograms.. J. Thorac. Cardiovasc. Surg. 135: 300-307 [Abstract] [Full Text]  
• Rybicki, F. J., Sheth, T., Chen, F. Y. (2008). Cardiac Surgical Imaging. Card Surg Adult 3: 179-198 [Full Text]  
• Dewey, T. M., Mack, M. J. (2008). Myocardial Revascularization without Cardiopulmonary Bypass. Card Surg Adult 3: 633-654 [Full Text]  
• Falk, V., Mohr, F. W. (2008). Minimally Invasive Myocardial Revascularization. Card Surg Adult 3: 697-710 [Full Text]  
• Hernandez, F. Jr, Brown, J. R., Likosky, D. S., Clough, R. A., Hess, A. L., Roth, R. M., Ross, C. S., Whited, C. M., O'Connor, G. T., Klemperer, J. D. (2007). Neurocognitive Outcomes of Off-Pump Versus On-Pump Coronary Artery Bypass: A Prospective Randomized Controlled Trial. Ann. Thorac. Surg. 84: 1897-1903 [Abstract] [Full Text]  
• Cho, K. R., Jeong, D. S., Kim, K.-B. (2007). Influence of vein graft use on postoperative 1-year results after off-pump coronary artery bypass surgery. Eur. J. Cardiothorac. Surg. 32: 718-723 [Abstract] [Full Text]  
• Onorati, F., Pezzo, F., Comi, M. C., Impiombato, B., Esposito, A., Polistina, M., Renzulli, A. (2007). Radial artery graft function is not affected by age.. J. Thorac. Cardiovasc. Surg. 134: 1112-1120 [Abstract] [Full Text]  
• Puskas, J. D., Steele, M. (2007). Would You Like Some Cardiopulmonary Bypass With Your Coronary Revascularization?. Circulation 116: 1756-1758 [Full Text]  
• Hannan, E. L., Wu, C., Smith, C. R., Higgins, R. S.D., Carlson, R. E., Culliford, A. T., Gold, J. P., Jones, R. H. (2007). Off-Pump Versus On-Pump Coronary Artery Bypass Graft Surgery: Differences in Short-Term Outcomes and in Long-Term Mortality and Need for Subsequent Revascularization. Circulation 116: 1145-1152 [Abstract] [Full Text]  
• Paparella, D., Cappabianca, G., Malvindi, P., Paramythiotis, A., Galeone, A., Veneziani, N., Fondacone, C., de Luca Tupputi Schinosa, L. (2007). Myocardial injury after off-pump coronary artery bypass grafting operation. Eur. J. Cardiothorac. Surg. 32: 481-487 [Abstract] [Full Text]  
• Anderson, J. L., Adams, C. D., Antman, E. M., Bridges, C. R., Califf, R. M., Casey, D. E. Jr, Chavey, W. E. II, Fesmire, F. M., Hochman, J. S., Levin, T. N., Lincoff, A. M., Peterson, E. D., Theroux, P., Wenger, N. K., Wright, R. S., Smith, S. C. Jr, Jacobs, A. K., Adams, C. D., Anderson, J. L., Antman, E. M., Halperin, J. L., Hunt, S. A., Krumholz, H. M., Kushner, F. G., Lytle, B. W., Nishimura, R., Ornato, J. P., Page, R. L., Riegel, B. (2007). ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction) Developed in Collaboration with the American College of Emergency Physicians, the Society for Cardiovascular Angiography and Interventions, and the Society of Thoracic Surgeons Endorsed by the American Association of Cardiovascular and Pulmonary Rehabilitation and the Society for Academic Emergency Medicine. J Am Coll Cardiol 50: e1-e157 [Full Text]  
• Botman, C. J., Schonberger, J., Koolen, S., Penn, O., Botman, H., Dib, N., Eeckhout, E., Pijls, N. (2007). Does Stenosis Severity of Native Vessels Influence Bypass Graft Patency? A Prospective Fractional Flow Reserve-Guided Study. Ann. Thorac. Surg. 83: 2093-2097 [Abstract] [Full Text]  
• Balacumaraswami, L., Taggart, D. P. (2007). Intraoperative Imaging Techniques to Assess Coronary Artery Bypass Graft Patency. Ann. Thorac. Surg. 83: 2251-2257 [Abstract] [Full Text]  
• Mulholland, J.W., Anderson, J.R., Yarham, G.J., Tuladhur, S., Saed, I., Oliver, M.D. (2007). Miniature cardiopulmonary bypass the Hammersmith experience. Perfusion 22: 161-166 [Abstract]  
• John, R., Lietz, K., Huddleston, S., Matas, A., Liao, K., Shumway, S., Joyce, L., Bolman, R. M. (2007). Perioperative outcomes of cardiac surgery in kidney and kidney pancreas transplant recipients. J. Thorac. Cardiovasc. Surg. 133: 1212-1219 [Abstract] [Full Text]  
• The Society of Thoracic Surgeons Blood Conservatio, , Ferraris, V. A., Ferraris, S. P., Saha, S. P., Hessel, E. A. II, Haan, C. K., Royston, B. D., Bridges, C. R., Higgins, R. S.D., Despotis, G., Brown, J. R., The Society of Cardiovascular Anesthesiologists Sp, , Spiess, B. D., Shore-Lesserson, L., Stafford-Smith, M., Mazer, C. D., Bennett-Guerrero, E., Hill, S. E., Body, S. (2007). Perioperative Blood Transfusion and Blood Conservation in Cardiac Surgery: The Society of Thoracic Surgeons and The Society of Cardiovascular Anesthesiologists Clinical Practice Guideline. Ann. Thorac. Surg. 83: S27-S86 [Abstract] [Full Text]  
• Gurbuz, A. T, Findik, O., Cui, H., Aytac, A. (2007). Radial Artery Graft Use and Off-Pump Coronary Artery Bypass Surgery Outcome. Asian Cardiovasc. Thorac. Ann. 15: 106-112 [Abstract] [Full Text]  
• Palmer, G., Herbert, M. A., Prince, S. L., Williams, J. L., Magee, M. J., Brown, P., Katz, M., Mack, M. J. (2007). Coronary Artery Revascularization (CARE) Registry: An Observational Study of On-Pump and Off-Pump Coronary Artery Revascularization. Ann. Thorac. Surg. 83: 986-992 [Abstract] [Full Text]  
• Bainbridge, D., Cheng, D., Martin, J., Novick, R., The Evidence-based Peri-operative Clinical Outcome, (2007). Does off-pump or minimally invasive coronary artery bypass reduce mortality, morbidity, and resource utilization when compared with percutaneous coronary intervention? A meta-analysis of randomized trials. J. Thorac. Cardiovasc. Surg. 133: 623-631 [Abstract] [Full Text]  
• van Dijk, D., Spoor, M., Hijman, R., Nathoe, H. M., Borst, C., Jansen, E. W. L., Grobbee, D. E., de Jaegere, P. P. T., Kalkman, C. J., for the Octopus Study Group, (2007). Cognitive and Cardiac Outcomes 5 Years After Off-Pump vs On-Pump Coronary Artery Bypass Graft Surgery. JAMA 297: 701-708 [Abstract] [Full Text]  
• Mahaffey, K. W., Roe, M. T., Kilaru, R., Alexander, J. H., Van de Werf, F., Califf, R. M., Simoons, M. L., Topol, E. J., Harrington, R. A. (2007). Creatine kinase-MB elevation after coronary artery bypass grafting surgery in patients with non-ST-segment elevation acute coronary syndromes predict worse outcomes: results from four large clinical trials. Eur Heart J 28: 425-432 [Abstract] [Full Text]  
• Takagi, H., Tanabashi, T., Kawai, N., Kato, T., Umemoto, T. (2007). Off-pump coronary artery bypass sacrifices graft patency: Meta-analysis of randomized trials. J. Thorac. Cardiovasc. Surg. 133: e2-e3 [Full Text]  
• Fukui, T., Takanashi, S., Hosoda, Y., Suehiro, S. (2007). Early and Midterm Results of Off-Pump Coronary Artery Bypass Grafting. Ann. Thorac. Surg. 83: 115-119 [Abstract] [Full Text]  
• Lim, E., Drain, A., Davies, W., Edmonds, L., Rosengard, B. R. (2006). A systematic review of randomized trials comparing revascularization rate and graft patency of off-pump and conventional coronary surgery. J. Thorac. Cardiovasc. Surg. 132: 1409-1413 [Abstract] [Full Text]  
• Sedrakyan, A., Wu, A. W., Parashar, A., Bass, E. B., Treasure, T. (2006). Off-Pump Surgery Is Associated With Reduced Occurrence of Stroke and Other Morbidity as Compared With Traditional Coronary Artery Bypass Grafting: A Meta-Analysis of Systematically Reviewed Trials * Supplemental Appendix I. Stroke 37: 2759-2769 [Full Text]  
• Desai, N. D., Miwa, S., Kodama, D., Koyama, T., Cohen, G., Pelletier, M. P., Cohen, E. A., Christakis, G. T., Goldman, B. S., Fremes, S. E. (2006). A randomized comparison of intraoperative indocyanine green angiography and transit-time flow measurement to detect technical errors in coronary bypass grafts. J. Thorac. Cardiovasc. Surg. 132: 585-594 [Abstract] [Full Text]  
• Martens, T. P., Argenziano, M., Oz, M. C. (2006). New Technology for Surgical Coronary Revascularization. Circulation 114: 606-614 [Full Text]  
• Parolari, A., Alamanni, F., Veglia, F., Tremoli, E., Biglioli, P. (2006). Reply. Ann. Thorac. Surg. 82: 770-771 [Full Text]  
• Takagi, H., Sugimoto, M., Kato, T., Matsuno, Y., Umemoto, T. (2006). Does Off-Pump Coronary Artery Bypass Graft Surgery Increase Risk of Graft Occlusion?. Ann. Thorac. Surg. 82: 769-770 [Full Text]  
• Rastan, A. J., Eckenstein, J. I., Hentschel, B., Funkat, A. K., Gummert, J. F., Doll, N., Walther, T., Falk, V., Mohr, F. W. (2006). Emergency Coronary Artery Bypass Graft Surgery for Acute Coronary Syndrome: Beating Heart Versus Conventional Cardioplegic Cardiac Arrest Strategies. Circulation 114: I-477-I-485 [Abstract] [Full Text]  
• El-Hamamsy, I., Cartier, R., Demers, P., Bouchard, D., Pellerin, M. (2006). Long-Term Results After Systematic Off-Pump Coronary Artery Bypass Graft Surgery in 1000 Consecutive Patients. Circulation 114: I-486-I-491 [Abstract] [Full Text]  
• Al-Ruzzeh, S., George, S., Bustami, M., Wray, J., Ilsley, C., Athanasiou, T., Amrani, M. (2006). Effect of off-pump coronary artery bypass surgery on clinical, angiographic, neurocognitive, and quality of life outcomes: randomised controlled trial. BMJ 332: 1365- [Abstract] [Full Text]  
• Lingaas, P. S., Hol, P. K., Lundblad, R., Rein, K. A., Mathisen, L., Smith, H.-J., Andersen, R., Thaulow, E., Tonnesen, T. I., Svennevig, J. L., Hauge, S. N., Fredriksen, P. M., Andersen, M., Fosse, E. (2006). Clinical and Radiologic Outcome of Off-Pump Coronary Surgery at 12 Months Follow-Up: A Prospective Randomized Trial. Ann. Thorac. Surg. 81: 2089-2095 [Abstract] [Full Text]  
• Beckermann, J., Van Camp, J., Li, S., Wahl, S. K., Collins, A., Herzog, C. A. (2006). On-pump versus off-pump coronary surgery outcomes in patients requiring dialysis: Perspectives from a single center and the United States experience. J. Thorac. Cardiovasc. Surg. 131: 1261-1266 [Abstract] [Full Text]  
• Michaux, I., Filipovic, M., Skarvan, K., Schneiter, S., Schumann, R., Zerkowski, H.-R., Bernet, F., Seeberger, M. D. (2006). Effects of on-pump versus off-pump coronary artery bypass graft surgery on right ventricular function. J. Thorac. Cardiovasc. Surg. 131: 1281-1288 [Abstract] [Full Text]  
• Authors/Task Force Members, , Fox, K., Garcia, M. A. A., Ardissino, D., Buszman, P., Camici, P. G., Crea, F., Daly, C., De Backer, G., Hjemdahl, P., Lopez-Sendon, J., Marco, J., Morais, J., Pepper, J., Sechtem, U., Simoons, M., Thygesen, K., ESC Committee for Practice Guidelines (CPG), , Priori, S. G., Blanc, J.-J., Budaj, A., Camm, J., Dean, V., Deckers, J., Dickstein, K., Lekakis, J., McGregor, K., Metra, M., Morais, J., Osterspey, A., Tamargo, J., Zamorano, J. L., Document Reviewers, , Zamorano, J. L, Andreotti, F., Becher, H., Dietz, R., Fraser, A., Gray, H., Antolin, R. A. H., Huber, K., Kremastinos, D. T., Maseri, A., Nesser, H.-J., Pasierski, T., Sigwart, U., Tubaro, M., Weis, M. (2006). Guidelines on the management of stable angina pectoris: executive summary: The Task Force on the Management of Stable Angina Pectoris of the European Society of Cardiology. Eur Heart J 27: 1341-1381 [Full Text]  
• Vernhet-Kovacsik, H., Battistella, P., Demaria, R., Pasquie, J. L., Bousquet, C., Dogas, G., Leclercq, F., Albat, B., Senac, J. P. (2006). Early Postoperative Assessment of Coronary Artery Bypass Graft Patency and Anatomy: Value of Contrast-Enhanced 16-MDCT with Retrospectively ECG-Gated Reconstructions. Am. J. Roentgenol. 186: S395-S400 [Abstract] [Full Text]  
• Kuduvalli, M., Newall, N., Stott, A., Grayson, A. D., Fabri, B. M. (2006). Impact of avoiding cardiopulmonary bypass for coronary surgery on perioperative cardiac enzyme release and survival.. Eur. J. Cardiothorac. Surg. 29: 729-735 [Abstract] [Full Text]  
• Argenziano, M., Katz, M., Bonatti, J., Srivastava, S., Murphy, D., Poirier, R., Loulmet, D., Siwek, L., Kreaden, U., Ligon, D., TECAB Trial Investigators, (2006). Results of the prospective multicenter trial of robotically assisted totally endoscopic coronary artery bypass grafting.. Ann. Thorac. Surg. 81: 1666-1675 [Abstract] [Full Text]  
• Mikhail, G W (2006). Coronary revascularisation in women. Heart 92: iii19-iii23 [Abstract] [Full Text]  
• Smedira, N. G., Dyke, C. M., Koster, A., Jurmann, M., Bhatia, D. S., Hu, T., McCarthy, H. L. II, Lincoff, A. M., Spiess, B. D., Aronson, S. (2006). Anticoagulation with bivalirudin for off-pump coronary artery bypass grafting: The results of the EVOLUTION-OFF study. J. Thorac. Cardiovasc. Surg. 131: 686-692 [Abstract] [Full Text]  
• Brown, J. M., Poston, R. S., Gammie, J. S., Cardarelli, M. G., Schwartz, K., Sikora, J. A. H., Yi, S., Pierson, R. N. III, Griffith, B. P. (2006). Off-Pump Versus On-Pump Coronary Artery Bypass Grafting in Consecutive Patients: Decision-Making Algorithm and Outcomes. Ann. Thorac. Surg. 81: 555-561 [Abstract] [Full Text]  
• Paparella, D., Galeone, A., Venneri, M. T., Coviello, M., Scrascia, G., Marraudino, N., Quaranta, M., de Luca Tupputi Schinosa, L., Brister, S. J. (2006). Activation of the coagulation system during coronary artery bypass grafting: Comparison between on-pump and off-pump techniques. J. Thorac. Cardiovasc. Surg. 131: 290-297 [Abstract] [Full Text]  
• Poston, R. S., Gu, J., Brown, J. M., Gammie, J. S., White, C., Nie, L., Pierson, R. N. III, Griffith, B. P. (2006). Endothelial injury and acquired aspirin resistance as promoters of regional thrombin formation and early vein graft failure after coronary artery bypass grafting. J. Thorac. Cardiovasc. Surg. 131: 122-130 [Abstract] [Full Text]  
• Parolari, A., Alamanni, F., Polvani, G., Agrifoglio, M., Chen, Y. B., Kassem, S., Veglia, F., Tremoli, E., Biglioli, P. (2005). Meta-Analysis of Randomized Trials Comparing Off-Pump With On-Pump Coronary Artery Bypass Graft Patency. Ann. Thorac. Surg. 80: 2121-2125 [Abstract] [Full Text]  
• Onorati, F., Olivito, S., Mastroroberto, P., di Virgilio, A., Esposito, A., Perrotti, A., Renzulli, A. (2005). Perioperative Patency of Coronary Artery Bypass Grafting is Not Influenced by Off-Pump Technique. Ann. Thorac. Surg. 80: 2132-2140 [Abstract] [Full Text]  
• Hassanein, W., Albert, A. A., Arnrich, B., Walter, J., Ennker, I. C., Rosendahl, U., Bauer, S., Ennker, J. (2005). Intraoperative Transit Time Flow Measurement: Off-Pump Versus On-Pump Coronary Artery Bypass. Ann. Thorac. Surg. 80: 2155-2161 [Abstract] [Full Text]  
• Nollert, G., Schwabenland, I., Maktav, D., Kur, F., Christ, F., Fraunberger, P., Reichart, B., Vicol, C. (2005). Miniaturized Cardiopulmonary Bypass in Coronary Artery Bypass Surgery: Marginal Impact on Inflammation and Coagulation but Loss of Safety Margins. Ann. Thorac. Surg. 80: 2326-2332 [Abstract] [Full Text]  
• Klima, U., Kofidis, T., Boening, A., Haverich, A. (2005). Long term angiographic monitoring reveals safety and efficacy of the Converge end-to-side anastomotic coupler. ICVTS 4: 505-508 [Abstract] [Full Text]  
• Babuin, L., Jaffe, A. S. (2005). Troponin: the biomarker of choice for the detection of cardiac injury. CMAJ 173: 1191-1202 [Abstract] [Full Text]  
• Desai, N. D., Miwa, S., Kodama, D., Cohen, G., Christakis, G. T., Goldman, B. S., Baerlocher, M. O., Pelletier, M. P., Fremes, S. E. (2005). Improving the Quality of Coronary Bypass Surgery With Intraoperative Angiography: Validation of a New Technique. J Am Coll Cardiol 46: 1521-1525 [Abstract] [Full Text]  
• Wijeysundera, D. N., Beattie, W. S., Djaiani, G., Rao, V., Borger, M. A., Karkouti, K., Cusimano, R. J. (2005). Off-Pump Coronary Artery Surgery for Reducing Mortality and Morbidity: Meta-Analysis of Randomized and Observational Studies. J Am Coll Cardiol 46: 872-882 [Abstract] [Full Text]  
• Zimarino, M., Calafiore, A. M., De Caterina, R. (2005). Complete myocardial revascularization: between myth and reality. Eur Heart J 26: 1824-1830 [Abstract] [Full Text]  
• Ruel, M., Suuronen, E. J., Song, J., Kapila, V., Gunning, D., Waghray, G., Rubens, F. D., Mesana, T. G. (2005). Effects of off-pump versus on-pump coronary artery bypass grafting on function and viability of circulating endothelial progenitor cells. J. Thorac. Cardiovasc. Surg. 130: 633-639 [Abstract] [Full Text]  
• Kobayashi, J., Tashiro, T., Ochi, M., Yaku, H., Watanabe, G., Satoh, T., Tagusari, O., Nakajima, H., Kitamura, S., for the Japanese Off-Pump Coronary Revascularizati, (2005). Early Outcome of a Randomized Comparison of Off-Pump and On-Pump Multiple Arterial Coronary Revascularization. Circulation 112: I-338-I-343 [Abstract] [Full Text]  
• Williams, M. L., Muhlbaier, L. H., Schroder, J. N., Hata, J. A., Peterson, E. D., Smith, P. K., Landolfo, K. P., Messier, R. H., Davis, R. D., Milano, C. A. (2005). Risk-Adjusted Short- and Long-Term Outcomes for On-Pump Versus Off-Pump Coronary Artery Bypass Surgery. Circulation 112: I-366-I-370 [Abstract] [Full Text]  
• Vedin, J., Antovic, A., Ericsson, A., Vaage, J. (2005). Hemostasis in Off-Pump Compared to On-Pump Coronary Artery Bypass Grafting: A Prospective, Randomized Study. Ann. Thorac. Surg. 80: 586-593 [Abstract] [Full Text]  
• Parolari, A., Mussoni, L., Frigerio, M., Naliato, M., Alamanni, F., Galanti, A., Fiore, G., Veglia, F., Tremoli, E., Biglioli, P., Camera, M. (2005). Increased prothrombotic state lasting as long as one month after on-pump and off-pump coronary surgery. J. Thorac. Cardiovasc. Surg. 130: 303-308 [Abstract] [Full Text]  
• Balacumaraswami, L., Abu-Omar, Y., Choudhary, B., Pigott, D., Taggart, D. P. (2005). A comparison of transit-time flowmetry and intraoperative fluorescence imaging for assessing coronary artery bypass graft patency. J. Thorac. Cardiovasc. Surg. 130: 315-320 [Abstract] [Full Text]  
• Calafiore, A. M., Di Giammarco, G., Teodori, G., Iaco, A. L., Pano, M., Contini, M., Vitolla, G., Di Mauro, M. (2005). Bilateral internal thoracic artery grafting with and without cardiopulmonary bypass: Six-year clinical outcome. J. Thorac. Cardiovasc. Surg. 130: 340-345 [Abstract] [Full Text]  
• Keenan, T. D.L., Abu-Omar, Y., Taggart, D. P. (2005). Bypassing the Pump: Changing Practices in Coronary Artery Surgery. Chest 128: 363-369 [Abstract] [Full Text]