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Editorial
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Volume 350:67-68 January 1, 2004 Number 1
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Use of Antiviral Drugs to Prevent Herpesvirus Transmission
Clyde S. Crumpacker, M.D.

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 by Corey, L.
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One of the main lessons of antiviral-drug therapy is that the drugs that inhibit viral replication are frequently more effective at preventing viral disease than they are at treating established disease. Acyclovir, for example, when taken on a daily basis, will prevent outbreaks of recurrent genital herpes infection, but when it is taken early to treat an episode of recurrent genital herpes, the result is a shortening of the course of disease by only one day — a marginal clinical benefit.1 Ganciclovir, the mainstay of therapy for cytomegalovirus (CMV) disease, has a similar effect. This drug was first used in . . . [Full Text of this Article]


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From the Division of Infectious Disease, Beth Israel Deaconess Medical Center, Boston.




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