FREE NEJM E-TOC    HOME   |   SUBSCRIBE   |   CURRENT ISSUE   |   PAST ISSUES   |   COLLECTIONS   |   Search Term  Advanced Search

Sign in | Get NEJM's E-Mail Table of Contents — Free | Subscribe

Volume 350:1071-1073 March 11, 2004 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

	Full Text PDF PDA Full Text Purchase this article Add to Personal Archive Add to Citation Manager Notify a Friend E-mail When Cited E-mail When Letters Appear Related Article by Choi, H. K. PubMed Citation

Gout is the only enemy that I do not wish to have at my feet.

— Reverend Sydney Smith, 1841

Gout, a disease that has been known since antiquity, is an acute, often recurrent arthritis mediated by the crystallization of uric acid within the joints and typically associated with hyperuricemia. Described by Hippocrates during the Golden Age of Greece, gout was originally a disease of the affluent, primarily observed in middle-aged men of the wealthy upper class ("the Patrician malady"). A "disease of kings and king of diseases," gout has often kept good company, afflicting kings (including Alexander the Great, . . . [Full Text of this Article]

Source Information

From the Division of Nephrology, Hypertension, and Transplantation, University of Florida, Gainesville (R.J.J.); and the Center for Reproduction of Endangered Species, Zoological Society of San Diego, San Diego, Calif. (B.A.R.).

This article has been cited by other articles:

• Matsuo, H., Takada, T., Ichida, K., Nakamura, T., Nakayama, A., Ikebuchi, Y., Ito, K., Kusanagi, Y., Chiba, T., Tadokoro, S., Takada, Y., Oikawa, Y., Inoue, H., Suzuki, K., Okada, R., Nishiyama, J., Domoto, H., Watanabe, S., Fujita, M., Morimoto, Y., Naito, M., Nishio, K., Hishida, A., Wakai, K., Asai, Y., Niwa, K., Kamakura, K., Nonoyama, S., Sakurai, Y., Hosoya, T., Kanai, Y., Suzuki, H., Hamajima, N., Shinomiya, N. (2009). Common Defects of ABCG2, a High-Capacity Urate Exporter, Cause Gout: A Function-Based Genetic Analysis in a Japanese Population. Sci Transl Med 1: 5ra11-5ra11 [Abstract] [Full Text]  
• Min, S. I., Yun, I. J., Kang, J. M., Park, Y. J., Min, S. K., Ahn, C., Kim, S. J., Ha, J. (2009). Moderate-to-severe early-onset hyperuricaemia: a prognostic marker of long-term kidney transplant outcome. Nephrol Dial Transplant 24: 2584-2590 [Abstract] [Full Text]  
• Feig, D. I., Soletsky, B., Johnson, R. J. (2008). Effect of Allopurinol on Blood Pressure of Adolescents With Newly Diagnosed Essential Hypertension: A Randomized Trial. JAMA 300: 924-932 [Abstract] [Full Text]  
• Sautin, Y. Y., Nakagawa, T., Zharikov, S., Johnson, R. J. (2007). Adverse effects of the classic antioxidant uric acid in adipocytes: NADPH oxidase-mediated oxidative/nitrosative stress. Am. J. Physiol. Cell Physiol. 293: C584-C596 [Abstract] [Full Text]  
• Nirenberg, M. S., Carroll, M. C. (2007). Atypical Gout in the Foot and Ankle Secondary to Primary Hyperparathyroidism. J. Am. Podiatr. Med. Assoc. 97: 245-247 [Full Text]  
• Sanchez-Lozada, L. G., Tapia, E., Jimenez, A., Bautista, P., Cristobal, M., Nepomuceno, T., Soto, V., Avila-Casado, C., Nakagawa, T., Johnson, R. J., Herrera-Acosta, J., Franco, M. (2007). Fructose-induced metabolic syndrome is associated with glomerular hypertension and renal microvascular damage in rats. Am. J. Physiol. Renal Physiol. 292: F423-F429 [Abstract] [Full Text]  
• Choi, H. K., Mount, D. B., Reginato, A. M. (2005). Pathogenesis of Gout. ANN INTERN MED 143: 499-516 [Full Text]  
• Masuo, K., Katsuya, T., Fu, Y., Rakugi, H., Ogihara, T., Tuck, M. L. (2005). Lys418Asn Polymorphism of the {alpha}2-Adrenoceptor Gene Relates to Serum Uric Acid Levels But Not to Insulin Sensitivity. Hypertension 46: 144-150 [Abstract] [Full Text]  
• (2004). Susceptibility to Gout: Diet Seems to Matter. JWatch General 2004: 3-3 [Full Text]