In the past 10 years, remarkable strides have been made in theunderstanding of the natural history and pathogenesis of hepatitisB virus (HBV) infection. In this article we will review theseadvances, with particular reference to the implications forantiviral therapy.
History
Clinical and epidemiologic studies began to differentiate amongvarious types of acute hepatitis in the decades after WorldWar II. The groundbreaking studies of Krugman and colleaguesin 1967 firmly established the existence of at least two typesof hepatitis,1 one of which (then called serum hepatitis, andnow called hepatitis B) was parenterally transmitted. Linksto the . . . [Full Text of this Article]
Virologic Features
Classification and Structure
Viral Genes and Proteins
Viral Replication Cycle
Pathogenesis of Hepatitis B
Natural History
Primary Infection
Persistent Infection
Hepatocellular Carcinoma
Implications for Therapy
Interferon
Antiviral Drugs
Lamivudine
Other Nucleotide Analogues
Liver Transplantation
Source Information
From the Departments of Microbiology and Immunology and Medicine and the Howard Hughes Medical Institute, University of California, San Francisco (D.G.); and the Laboratory of Virology, Lindsley F. Kimball Research Institute, New York Blood Center, and the Department of Pathology, New York University School of Medicine — both in New York (A.M.P.).
Address reprint requests to Dr. Prince at the Laboratory of Virology, Lindsley F. Kimball Research Institute, New York Blood Center, 310 E. 67th St., New York, NY 10021, or at aprince@nybloodcenter.org.
Related Letters:
Hepatitis B
Janssen H. L.A., van Zonneveld M., Schalm S. W., Mohamadnejad M., Malekzadeh R.
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N Engl J Med 2004;
350:2719-2720, Jun 24, 2004.
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A correction has been published: N Engl J Med 2004;351(12):1268.
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