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Previous Volume 350:1140-1142 March 11, 2004 Number 11 Next

	Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings.

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Since Sir George Beatson observed in 1896 that breast tumors in premenopausal women sometimes regressed after oophorectomy,¹ numerous investigations have established that estrogen stimulates the growth of breast-cancer cells. Three newer strategies reduce the growth-stimulating signals of estrogen: interfering with the binding of estrogen to its receptor, the primary mode of action of the antiestrogen agent tamoxifen in premenopausal and postmenopausal women; decreasing the estrogen levels in the blood and the tumor, the mechanism of action of aromatase inhibitors in postmenopausal women; and destroying the estrogen receptor, which is how the drug fulvestrant exerts its antitumor activity.

During the course . . . [Full Text of this Article]

Source Information

From the Jules Bordet Institute, Brussels, Belgium.

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