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The year 2003 marked not only the 50th anniversary of the discovery of the structure of DNA but also the 50th anniversary of the first description of invasive aspergillosis as an opportunistic infection. The publication of this report by Rankin in the British Medical Journal (1953;1:918-919.) ushered in a new era in the study of infectious diseases, that of the immunocompromised patient and opportunistic infections. A year later, syngeneic renal transplantation was achieved, with long-term survival, and bone marrow transplantation was first attempted in 1957. Thus began a new subspecialty transplantation medicine. The frequency and severity of numerous infections
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