Epstein–Barr virus (EBV) is perhaps best known for itsability to immortalize human B lymphocytes in culture.1 Thisproperty makes it a candidate for causing human disease, particularlycancer and autoimmune disease.2,3 Recent work, however, hasshown that EBV has evolved strategies that reduce its potentialto become pathogenic.4,5,6 These new findings have encourageda reassessment of how and when EBV may cause human disease.In this article, we review current knowledge of the ways inwhich EBV establishes and maintains a persistent infection atthe same time that it minimizes its pathogenicity; we also discusshow these characteristics influence . . . [Full Text of this Article]
EBV Infection
In Vitro and in Vivo Infection
The Persistence of EBV
Resolution of the Infection
Minimizing the Pathogenic Effect of EBV
Other Interpretations
EBV and Epithelium
EBV and Disease
Lymphoma in Immunosuppressed Patients
Hodgkin's Disease
Burkitt's Lymphoma
Conclusions
Source Information
From the Department of Pathology, Tufts University School of Medicine (D.A.T.-L.), and the Department of Rheumatology, Tufts–New England Medical Center (A.G.) — both in Boston.
Address reprint requests to Dr. Thorley-Lawson at the Department of Pathology, Jaharis Bldg., Tufts University School of Medicine, 150 Harrison Ave., Boston, MA 02111, or at david.thorley-lawson@tufts.edu.
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