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Volume 350:1353-1356 March 25, 2004 Number 13
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Derivation of Embryonic Stem-Cell Lines from Human Blastocysts
Chad A. Cowan, Ph.D., Irina Klimanskaya, Ph.D., Jill McMahon, M.S., Jocelyn Atienza, B.S., Jeannine Witmyer, Ph.D., Jacob P. Zucker, B.S., Shunping Wang, Ph.D., Cynthia C. Morton, Ph.D., Andrew P. McMahon, Ph.D., Doug Powers, Ph.D., and Douglas A. Melton, Ph.D.

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 by Gearhart, J.
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 by Phimister, E. G.

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Embryonic stem cells have the unique ability to form all adult cell types. Harnessing this potential may provide a source of cells to replace those that are lost or impaired as a result of disease. Moreover, the derivation of human embryonic stem cells opens a unique window into the study of early human development. At present, approximately 15 human embryonic stem-cell lines are publicly available, and they vary considerably in their usefulness for research and the extent of their characterization (see http://stemcells.nih.gov/registry/index.asp). To promote further research with human embryonic stem cells, we sought to derive and characterize more fully . . . [Full Text of this Article]


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From the Howard Hughes Medical Institute (C.A.C., I.K., J.M., J.A., J.P.Z., D.A.M.) and the Department of Molecular and Cellular Biology (C.A.C., I.K., J.M., J.A., J.P.Z., A.P.M., D.A.M.), Harvard University, Cambridge, Mass.; Boston IVF, Waltham, Mass. (J.W., S.W., D.P.); and the Department of Obstetrics, Gynecology, and Reproductive Biology and Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston (C.C.M.).

This article was published at www.nejm.org on March 3, 2004.


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