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Correspondence
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Volume 350:1364-1365 March 25, 2004 Number 13
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A Patient with Two Ewing's Sarcomas with Distinct EWS Fusion Transcripts

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To the Editor: Members of the Ewing's family of tumors are characterized by rearrangements involving the EWS gene on chromosome 22q12 and fusion partners from the ETS oncogene family, most frequently FLI1 on chromosome 11q24 (frequency, 85 percent) or ERG on chromosome 21q22 (10 percent).1,2,3 So far, it is believed that one particular rearrangement is specific for any given Ewing's tumor and that no molecular shift occurs during progression. We describe a patient in whom two separate Ewing's tumors with distinct EWS translocations developed.

A 14-year-old girl without a family history of cancer was referred for the treatment of a . . . [Full Text of this Article]



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