Perhaps the earliest link between oral leukoplakia and cancerwas made by James Paget, for whom Paget's disease was named;he also recognized the connection between oral leukoplakia andsmoking. Leukoplakia is a clinical term that refers to an oralmucosal white patch that will not rub off and is not attributableto any other known disease. It is considered to be potentiallymalignant, with a transformation rate in various studies andlocations ranging from 0.6 to 18 percent. Clinically, oral leukoplakiais in the same spectrum of disease as the more sinister redor speckled lesion erythroplakia, which has . . . [Full Text of this Article]
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From the Departments of Stomatology (D.G., R.C.K.J.) and Pathology (R.C.K.J.), University of California at San Francisco, San Francisco.
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